The association of hemocyte profile and obstructive sleep apnea

• Published in: Journal of clinical laboratory analysis Vol. 33; no. 2; pp. e22680 - n/a
• Main Authors: Fan, Zeqin, Lu, Xiaoxia, Long, Hong, Li, Taoping, Zhang, Yanhong
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.02.2019; John Wiley and Sons Inc
• Subjects: Adult; Apnea; Blood; blood cell; Blood Cells - cytology; Body mass index; Erythrocytes; Hematocrit; Hematologic Tests; hemocyte profile; Hemoglobin; Humans; Leukocytes (basophilic); Leukocytes (eosinophilic); Leukocytes (neutrophilic); Lymphocytes; Male; Middle Aged; Monocytes; Neutrophils; obstructive sleep apnea; Platelets; Polysomnography; Retrospective Studies; Sleep; Sleep apnea; Sleep Apnea, Obstructive - blood; Sleep Apnea, Obstructive - epidemiology; Sleep disorders; Statistical analysis; blood cell; obstructive sleep apnea; hematocrit; lymphocytes; neutrophils; hemocyte profile
• ISSN: 0887-8013; 1098-2825
• DOI: 10.1002/jcla.22680

Background The hemocyte profile is one of the most frequently requested clinical laboratory tests. However, the analysis of blood cell indexes of obstructive sleep apnea (OSA) patients in previous studies was not comprehensive. And, this study aimed to fully analyze the blood routine in OSA patients. Methods A retrospective study was conducted on 1087 male patients, who were admitted to the sleep center of Nanfang Hospital from May 2013 to February 2018. According to the apnea hypopnea index (AHI), patients were divided into four groups: control group (AHI < 5, n = 135), mild OSA (5 ≦ AHI < 15, n = 185), moderate OSA (15 ≦ AHI < 30, n = 171), and severe OSA (AHI ≧ 30, n = 596). Data collected included sleep parameters, complete blood routine, body mass index (BMI), age, and comorbidities. Results In our study, leukocytes, neutrophils, lymphocytes, monocytes, eosinophils, basophils, erythrocytes, hemoglobin, hematocrit, platelets, MPV, and PDW‐SD were statistically significant among the four groups based on AHI (P < 0.05), but no significant differences were found in MCV, RDW‐SD, N/L, and P/L ratio (P > 0.05). Neutrophils, lymphocytes, monocytes, eosinophils, basophils, hemoglobin, hematocrit, platelets, and MPV were significantly correlated with AHI. Moreover, multiple linear regression analysis demonstrated that hematocrit (β = 73.254, P = 0.001), neutrophils (β = 1.414, P = 0.012), and lymphocytes (β = 4.228, P < 0.001) were independently associated with AHI. Conclusion Neutrophils, lymphocytes, and hematocrit were independently associated with OSA severity. And combining these three blood cell indicators could contribute to the diagnosis of OSA.