Ultra low concentrated molecular detection using super hydrophobic surface based biophotonic devices

Micro and nano-patterned devices were fabricated which disclose the possibility of concentrating, localizing, detecting and thus analyzing with unprecedented accuracy few molecules (at the limit a single molecule) of biological and medical interest. Important applications are envisioned where protei...

Full description

Saved in:
Bibliographic Details
Published inMicroelectronic engineering Vol. 87; no. 5; pp. 798 - 801
Main Authors Gentile, F., Das, G., Coluccio, M.L., Mecarini, F., Accardo, A., Tirinato, L., Tallerico, R., Cojoc, G., Liberale, C., Candeloro, P., Decuzzi, P., De Angelis, F., Di Fabrizio, E.
Format Journal Article Conference Proceeding
LanguageEnglish
Published Amsterdam Elsevier B.V 01.05.2010
Elsevier
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:Micro and nano-patterned devices were fabricated which disclose the possibility of concentrating, localizing, detecting and thus analyzing with unprecedented accuracy few molecules (at the limit a single molecule) of biological and medical interest. Important applications are envisioned where proteins poorly concentrated in blood are detected thus (early) revealing the appearance of diseases. The major advance of the paper is that it combines micro/nano-fabrication and spectroscopical nano-optics based techniques to study and individualize the biomolecules at study. Super hydrophobic surface would concentrate the diluted solution into a small area whereas spectroscopical nano-optics techniques would gather the molecular/chemical information of the residual solute. Fluorescence and SERS techniques were used to analyze Rhodamine molecules initially highly diluted (10 −18 M).
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0167-9317
1873-5568
DOI:10.1016/j.mee.2009.11.083