Neuromagnetic auditory response and its relation to cortical thickness in ultra-high-risk for psychosis

• Published in: Schizophrenia research Vol. 140; no. 1; pp. 93 - 98
• Main Authors: Shin, Kyung Soon, Jung, Wi Hoon, Kim, June Sic, Jang, Joon Hwan, Hwang, Jae Yeon, Chung, Chun Kee, Kwon, Jun Soo
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.09.2012; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Analysis of Variance; Auditory Perceptual Disorders - diagnosis; Auditory Perceptual Disorders - etiology; Biological and medical sciences; Cerebral Cortex - pathology; Cortical thickness; Dipole analysis; Evoked Potentials, Auditory - physiology; Female; Humans; M100; Magnetic Resonance Imaging; Magnetoencephalography; Male; Medical sciences; Psychiatric Status Rating Scales; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Risk; Schizophrenia; Schizophrenia - complications; Schizophrenia - pathology; Ultra-high-risk; Young Adult; Schizophrenia; Ultra-high-risk; Cortical thickness; Dipole analysis; Magnetoencephalography; M100; Human; High risk; Central nervous system; Encephalon; Psychosis; Hearing; Perception; Prepsychotic state
• ISSN: 0920-9964; 1573-2509
• DOI: 10.1016/j.schres.2012.06.014

Abstract Background Higher cognitive dysfunction, lower perceptual disturbance and its relation to the structures that implicate such processes have been considered as key features in patients with schizophrenia. However, little is known about the relationship between perceptual processing and structural deficits in ultra-high-risk for psychosis. Methods We investigated the dipole moment of M100 auditory evoked response using a magnetoencephalography in 18 patients with schizophrenia, 16 ultra-high-risk for psychosis and 16 healthy controls, and their relation to cortical thinning on Heschl's gyrus and planum temporale. Results The auditory evoked M100 dipole moment was decreased in the ultra-high-risk subjects and in the patients with schizophrenia. Ultra-high-risk subjects showed impaired right M100 dipole magnitude, similar to patients with schizophrenia. Robust correlations between the cortical thickness of left Heschl's gyrus and the left M100 dipole moment were found in patients with schizophrenia. Moreover, correlations were also evident between right Heschl's gyrus and right M100 in subjects at ultra-high-risk for psychosis. Conclusions The primary feature of auditory perception in ultra-high-risk subjects and schizophrenia patients is an encoding deficit that manifests as a reduced M100 dipole moment. The relationship between abnormal M100, thinning of cortical generators and their symptomatology were shown to exist prior to the onset of overt psychosis and progressively worsen over time. Therefore, they may be a potential indicator of the development of schizophrenia.