Association of procalcitonin with voriconazole concentrations: a retrospective cohort study

• Published in: BMC infectious diseases Vol. 24; no. 1; pp. 952 - 8
• Main Authors: Zhou, Ju-Xiang, Xiong, Chun-Lin, Chang, Zao-Shang, Yin, You-Cong, Su, Kai-Peng, Zhang, Ji-Hong, Wu, Ji-Chu, Sun, Bao
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.09.2024; BioMed Central; BMC
• Subjects: Adult; Age; Aged; Albumin; Albumins; Antifungal Agents - blood; Antifungal Agents - therapeutic use; Bacterial diseases; Bacterial infections; Bilirubin; Biomarkers; Biomarkers - blood; Cohort analysis; Drug dosages; Drug Monitoring; Female; Fungal infections; Humans; Hypoalbuminemia; Infections; Infectious diseases; Inflammation; Male; Middle Aged; Overdose; Patients; Peptides; Pharmacology, Experimental; Physiological aspects; Plasma; Plasma concentration; Procalcitonin; Procalcitonin - blood; Regression analysis; Retrospective Studies; Risk factors; Sex; Software; Therapeutic drug monitoring; Voriconazole; Voriconazole - blood; China; Hypoalbuminemia; Infections; Procalcitonin; Plasma concentration; Voriconazole
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-024-09862-4

Inflammation is a potential risk factor of voriconazole (VCZ) overdose, procalcitonin (PCT) is reported to act as a diagnostic marker for bacterial infections. However, the association of PCT with VCZ trough serum concentrations (VCZ-C ) is not fully clear. Our study aims to investigate the associations between PCT and VCZ-C . In this retrospective cohort study, we collected the clinical data of 147 patients who received VCZ and monitored the VCZ concentration of them in our hospital from August 2017 to August 2021. All patients underwent routine clinical examinations on the day or the day before VCZ administration. General information and clinical symptoms of these patients were recorded. Multivariate liner analysis showed that PCT was significantly associated with VCZ-C (p < 0.001). Overall, it was shown that VCZ-C was significantly increased by 0.32 µg/mL for each fold increment in PCT in crude model. In the minor adjusted model (Model 1, adjustment for sex, age, albumin, direct bi1irubin, WBC) and fully adjusted model (Model 2, adjustment for sex, age, albumin, direct bilirubin, WBC, AST and ALT), VCZ-C was significantly increased by 0.23 µg/mL and 0.21 µg/mL, respectively, for each fold increment in PCT. In conclusion, this research reveals the correlation between PCT and VCZ-C , indicating that PCT has the potential to serve as a valuable biomarker for drug monitoring in the treatment of VCZ.