Mechanism and Control of Meiotic DNA Double-Strand Break Formation in S. cerevisiae

Developmentally programmed formation of DNA double-strand breaks (DSBs) by Spo11 initiates a recombination mechanism that promotes synapsis and the subsequent segregation of homologous chromosomes during meiosis. Although DSBs are induced to high levels in meiosis, their formation and repair are tig...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in cell and developmental biology Vol. 9; p. 642737
Main Authors Yadav, Vikash Kumar, Claeys Bouuaert, Corentin
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 02.03.2021
Subjects
Cell and Developmental Biology
DNA recombination
double-strand break
meiosis
phase separation
Spo11
double-strand break
phase separation
meiosis
Spo11
DNA recombination
Online AccessGet full text

Cover

More Information
Summary:Developmentally programmed formation of DNA double-strand breaks (DSBs) by Spo11 initiates a recombination mechanism that promotes synapsis and the subsequent segregation of homologous chromosomes during meiosis. Although DSBs are induced to high levels in meiosis, their formation and repair are tightly regulated to minimize potentially dangerous consequences for genomic integrity. In , nine proteins participate with Spo11 in DSB formation, but their molecular functions have been challenging to define. Here, we describe our current view of the mechanism of meiotic DSB formation based on recent advances in the characterization of the structure and function of DSB proteins and discuss regulatory pathways in the light of recent models.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Reviewed by: Bernard De Massy, Université de Montpellier, France; Valérie Borde, Centre National de la Recherche Scientifique (CNRS), France
This article was submitted to Cell Growth and Division, a section of the journal Frontiers in Cell and Developmental Biology
Edited by: Akira Shinohara, Osaka University, Japan
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2021.642737