Evaluating adaptive evolution

Using comparative sequence analyses, we can identify proteins that may have been subject to positive darwinian selection. To test these statistical results, it is important to develop functional assays and identify amino-acid changes that are responsible for the adaptation of organisms to specific e...

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Bibliographic Details
Published inNature genetics Vol. 30; no. 4; pp. 350 - 351
Main Author Yokoyama, Shozo
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.04.2002
Nature Publishing Group
Subjects
Agriculture
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Biomedicine
Cancer Research
Colobinae
Evolution
Evolution, Molecular
Gene Function
Genetic aspects
Human Genetics
Mutation
news-and-views
Physiological aspects
Ribonuclease
Ribonuclease, Pancreatic - genetics
RNA
RNA - metabolism
Selection, Genetic
United States
Online AccessGet full text
ISSN1061-4036
1546-1718
DOI10.1038/ng0402-350

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Summary:Using comparative sequence analyses, we can identify proteins that may have been subject to positive darwinian selection. To test these statistical results, it is important to develop functional assays and identify amino-acid changes that are responsible for the adaptation of organisms to specific environments. One of the two duplicated pancreatic ribonuclease genes of a leaf-eating colobine monkey, douc langur, is now shown to have adapted to digest bacterial RNAs in the monkey's foregut.
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ISSN:1061-4036
1546-1718
DOI:10.1038/ng0402-350