Mast Cell-Derived Exosomes Induce Phenotypic and Functional Maturation of Dendritic Cells and Elicit Specific Immune Responses In Vivo

• Published in: The Journal of immunology (1950) Vol. 170; no. 6; pp. 3037 - 3045
• Main Authors: Skokos, Dimitris, Botros, Hany Goubran, Demeure, Christian, Morin, Joelle, Peronet, Roger, Birkenmeier, Gerd, Boudaly, Sarah, Mecheri, Salaheddine
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.03.2003; Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists
• Subjects: Adaptive immunology; Allergology; Animals; Antigen Presentation; Antigen-Presenting Cells - immunology; Antigen-Presenting Cells - metabolism; Bone Marrow Cells - cytology; Bone Marrow Cells - immunology; Bone Marrow Cells - metabolism; Cattle; Cell Behavior; Cell Differentiation - immunology; Cellular Biology; Chaperonin 60 - immunology; Chaperonin 60 - metabolism; Cytoplasmic Vesicles - immunology; Cytoplasmic Vesicles - metabolism; Dendritic Cells - cytology; Dendritic Cells - immunology; Endocytosis - immunology; HSC70 Heat-Shock Proteins; HSP70 Heat-Shock Proteins - immunology; HSP70 Heat-Shock Proteins - metabolism; Immunology; Immunophenotyping; Innate immunity; Life Sciences; Low Density Lipoprotein Receptor-Related Protein-1 - physiology; Mast Cells - cytology; Mast Cells - immunology; Mast Cells - metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred DBA; Transferrin - immunology; Transferrin - metabolism

Mast cells (MCs) are considered major players in IgE-mediated allergic responses, but have also recently been recognized as active participants in innate as well as specific immune responses. Recent work provided evidence that MCs are able to activate B and T lymphocytes through the release of vesic...