Decreased functional connectivity in an executive control network is related to impaired executive function in Internet gaming disorder

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 57; pp. 76 - 85
• Main Authors: Dong, Guangheng, Lin, Xiao, Potenza, Marc N.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 03.03.2015
• Subjects: Behavior, Addictive - physiopathology; Behavior, Addictive - psychology; Behavioral addiction; Brain - physiopathology; Brain Mapping; Case-Control Studies; Executive control network; Executive Function - physiology; Functional connectivity; Humans; Internet - utilization; Internet gaming disorder; Magnetic Resonance Imaging; Male; Neural Pathways - physiopathology; Resting state fMRI; Stroop Test; Video Games - psychology; Young Adult; Functional connectivity; IGD; Resting state fMRI; IAD; ROI; ECN; fMRI; Internet gaming disorder; HC; IAT; FC; DSM; Behavioral addiction; Executive control network
• ISSN: 0278-5846; 1878-4216; 1878-4216
• DOI: 10.1016/j.pnpbp.2014.10.012

Resting brain spontaneous neural activities across cortical regions have been correlated with specific functional properties in psychiatric groups. Individuals with Internet gaming disorder (IGD) demonstrate impaired executive control. Thus, it is important to examine executive control networks (ECNs) during resting states and their relationships to executive control during task performance. Thirty-five IGD and 36 healthy control participants underwent a resting-state fMRI scan and performed a Stroop task inside and outside of the MRI scanner. Correlations between Stroop effect and functional connectivity among ECN regions of interest (ROIs) were calculated within and between groups. IGD subjects show lower functional connectivity in ECNs than do HC participants during resting state; functional-connectivity measures in ECNs were negatively correlated with Stroop effect and positively correlated with brain activations in executive-control regions across groups. Within groups, negative trends were found between Stroop effect and functional connectivity in ECNs in IGD and HC groups, separately; positive trends were found between functional connectivity in ECNs and brain activations in Stroop task in IGD and HC groups, separately. Higher functional connectivity in ECNs may underlie better executive control and may provide resilience with respect to IGD. Lower functional connectivity in ECNs may represent an important feature in understanding and treating IGD. •Lower FC in ECNs in IGD than in HC•Positive trends between FC in ECNs and brain activations in Stroop task•The FC in ECNs may represent an important feature in IGD.