A Multiscale Model of Venous Thrombus Formation with Surface-Mediated Control of Blood Coagulation Cascade

• Published in: Biophysical journal Vol. 98; no. 9; pp. 1723 - 1732
• Main Authors: Xu, Zhiliang, Lioi, Joshua, Mu, Jian, Kamocka, Malgorzata M., Liu, Xiaomin, Chen, Danny Z., Rosen, Elliot D., Alber, Mark
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.05.2010; Biophysical Society; The Biophysical Society
• Subjects: Algorithms; Animals; Biological Systems and Multicellular Dynamics; Blood; Blood clots; Blood Coagulation; Blood platelets; Blood vessels; Coagulation; Delay; Factor VII - metabolism; Low level; Mathematical models; Membranes; Mice; Models, Biological; Pathways; Porosity; Protein C - metabolism; Proteins; Surface reactions; Thrombin; Thrombin - biosynthesis; Tissues; Venous Thrombosis - blood; Venous Thrombosis - metabolism
• ISSN: 0006-3495; 1542-0086
• DOI: 10.1016/j.bpj.2009.12.4331

A combination of the extended multiscale model, new image processing algorithms, and biological experiments is used for studying the role of Factor VII (FVII) in venous thrombus formation. A detailed submodel of the tissue factor pathway of blood coagulation is introduced within the framework of the multiscale model to provide a detailed description of coagulation cascade. Surface reactions of the extrinsic coagulation pathway on membranes of platelets are studied under different flow conditions. It is shown that low levels of FVII in blood result in a significant delay in thrombin production, demonstrating that FVII plays an active role in promoting thrombus development at an early stage.