BoDV-1 Infection in Children and Adolescents: A Systematic Review and Meta-Analysis

Borna disease virus 1 (BoDV-1) can cause a severe human syndrome characterized by meningo-myeloencephalitis. The actual epidemiology of BoDV-1 remains disputed, and our study summarized prevalence data among children and adolescents (<18-year-old). Through systematic research on three databases (...

Full description

Saved in:
Bibliographic Details
Published inPediatric reports Vol. 15; no. 3; pp. 512 - 531
Main Authors Riccò, Matteo, Zanella, Ilaria, Satta, Elia, Ranzieri, Silvia, Corrado, Silvia, Marchesi, Federico, Peruzzi, Simona
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.09.2023
MDPI
Subjects
Adolescents
Animals
Antibodies
Antigens
BoDV-1
Borna disease
Borna virus
Bornavirus
Children
ELISA
Encephalitis
Epidemiology
Genomes
Heterogeneity
Infections
meningo-myeloencephalitis
Meta-analysis
Pathogens
Pediatrics
Schizophrenia
Serology
seroprevalence
Systematic Review
Teenagers
Vectors
Viruses
Japan
Germany
Bornavirus
seroprevalence
meningo-myeloencephalitis
BoDV-1
ELISA
Online AccessGet full text

Cover

More Information
Summary:Borna disease virus 1 (BoDV-1) can cause a severe human syndrome characterized by meningo-myeloencephalitis. The actual epidemiology of BoDV-1 remains disputed, and our study summarized prevalence data among children and adolescents (<18-year-old). Through systematic research on three databases (PubMed, EMBASE, MedRxiv), all studies, including seroprevalence rates for BoDV-1 antigens and specific antibodies, were retrieved, and their results were summarized. We identified a total of six studies for a total of 2692 subjects aged less than 18 years (351 subjects sampled for BoDV-1 antibodies and 2557 for antigens). A pooled seroprevalence of 6.09% (95% Confidence Interval [95% CI] 2.14 to 16.17) was eventually calculated for BoDV-1 targeting antibodies and 0.76% (95% CI 0.26 to 2.19) for BoDV-1 antigens. Both estimates were affected by substantial heterogeneity. Seroprevalence rates for BoDV-1 in children and adolescents suggested that a substantial circulation of the pathogen does occur, and as infants and adolescents have relatively scarce opportunities for being exposed to hosts and animal reservoirs, the potential role of unknown vectors cannot be ruled out.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 14
ObjectType-Feature-3
ObjectType-Evidence Based Healthcare-1
ObjectType-Article-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:2036-7503
2036-749X
2036-7503
DOI:10.3390/pediatric15030047