Liquid chromatography-tandem mass spectrometry method for the determination of thiosulfate in human blood and urine as an indicator of hydrogen sulfide poisoning

Highlights • Quantitative determination method for thiosulfate by LC-MS/MS was developed. • Thiosulfate can be utilized for an index of hydrogen sulfide poisoning. • The established method is more rapid and simple comparing to GC/MS method. • The method could estimate thiosulfate concentrations in 1...

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Published inLegal medicine (Tokyo, Japan) Vol. 24; pp. 67 - 74
Main Authors Maseda, Chikatoshi, Hayakawa, Akira, Okuda, Katsuhiro, Asari, Masaru, Tanaka, Hiroki, Yamada, Hiromi, Jin, Shigeki, Horioka, Kie, Matoba, Kotaro, Shiono, Hiroshi, Matsubara, Kazuo, Shimizu, Keiko
Format Journal Article
LanguageEnglish
Published Ireland Elsevier B.V 01.01.2017
Subjects
Chromatography, Liquid - methods
Forensic Toxicology
Humans
Hydrogen sulfide
Hydrogen Sulfide - poisoning
Internal Medicine
LC-MS/MS
Qualitative Research
Quantitative determination
Tandem Mass Spectrometry - methods
Thiosulfate
Thiosulfates - blood
Thiosulfates - urine
Hydrogen sulfide
LC-MS/MS
Thiosulfate
Quantitative determination
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Summary:Highlights • Quantitative determination method for thiosulfate by LC-MS/MS was developed. • Thiosulfate can be utilized for an index of hydrogen sulfide poisoning. • The established method is more rapid and simple comparing to GC/MS method. • The method could estimate thiosulfate concentrations in 12 forensic autopsy cases.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1344-6223
1873-4162
DOI:10.1016/j.legalmed.2016.12.004