Does thyroid-stimulating hormone influence the prognosis of patients with endometrial cancer? A multicentre trial

• Published in: British journal of cancer Vol. 109; no. 1; pp. 215 - 218
• Main Authors: Seebacher, V, Hofstetter, G, Polterauer, S, Reinthaller, A, Grimm, C, Schwameis, R, Taucher, S, Wagener, A, Marth, C, Concin, N
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.07.2013; Nature Publishing Group
• Subjects: 692/699/67/1517/1931; 692/700/1750; Aged; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cancer therapies; Diabetes; Drug Resistance; Endometrial cancer; Endometrial Neoplasms - blood; Endometrial Neoplasms - metabolism; Endometrial Neoplasms - mortality; Epidemiology; Female; Female genital diseases; Gynecology; Gynecology. Andrology. Obstetrics; Humans; Hypertension; Hypothyroidism; Kaplan-Meier Estimate; Lymphatic system; Medical prognosis; Medical sciences; Molecular Medicine; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Obstetrics; Oncology; Prognosis; Short Communication; Statistical analysis; Survival analysis; Thyroid gland; Thyroid Gland - physiology; Thyrotropin - blood; Tumors; Austria; Germany; thyroid-stimulating hormone; endometrial cancer; thyroid gland; hypothyroidism; prognosis; survival; Endocrinopathy; Human; Endometrium cancer; Endocrine gland; Prognosis; Thyroid diseases; Thyroid stimulating hormone; Thyroid gland; Malignant tumor; Hypothyroidism; Survival; Female genital diseases; Cancerology; Adenohypophyseal hormone; Uterine diseases; Clinical trial; Cancer
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/bjc.2013.282

Background: Thyroid function has been suggested to interfere with tumour biology and prognosis in different cancers. The present study was performed to investigate the impact of pre-therapeutic serum thyroid-stimulating hormone (TSH) levels on the prognosis of patients with endometrial cancer. Methods: Pre-therapeutic serum TSH was investigated in 199 patients with endometrial cancer. After stratification in TSH risk groups, univariate and multivariable survival analyses were performed. Results: Elevated TSH was independently associated with poor disease-specific survival in univariate/multivariable survival analyses ( P =0.01 and P =0.03, respectively). Conclusion: Thyroid-stimulating hormone may serve as a novel and independent prognostic parameter for disease-specific survival in patients with endometrial cancer.