Autoantibodies in Sjögren's Syndrome

We compiled information on antibodies in Sjögren syndrome, focusing more on clinical manifestations associated with anti-Ro/SSA and anti-La/SSB antibodies and studies regarding novel antibodies. We reviewed previous as well as most recent studies with the subject heading Sjogren in combination with...

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Bibliographic Details
Published inRheumatic diseases clinics of North America Vol. 42; no. 3; p. 419
Main Authors Fayyaz, Anum, Kurien, Biji T, Scofield, R Hal
Format Journal Article
LanguageEnglish
Published United States 01.08.2016
Subjects
Antibodies, Antinuclear - immunology
Autoantibodies - immunology
Autoantibodies - metabolism
Disease Progression
Female
Heart Block - congenital
Heart Block - immunology
Humans
Infant, Newborn
Lupus Erythematosus, Systemic - congenital
Lupus Erythematosus, Systemic - immunology
Peptides, Cyclic - immunology
Pregnancy
Receptor, Muscarinic M3 - immunology
Rheumatoid Factor - immunology
Sjogren's Syndrome - immunology
Congenital heart block
Sjögren’s syndrome
Autoantibodies
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Summary:We compiled information on antibodies in Sjögren syndrome, focusing more on clinical manifestations associated with anti-Ro/SSA and anti-La/SSB antibodies and studies regarding novel antibodies. We reviewed previous as well as most recent studies with the subject heading Sjogren in combination with antibodies and congenital heart block (CHB). Almost half of asymptomatic mothers giving birth to children with CHB ultimately develop Sjögren. We discussed studies concerning the presence of antibodies predating clinical manifestations of disease. Studies in the future are required to ascertain the pathogenic mechanisms associated with these antibodies and the specific clinical manifestation related to new autoantibodies.
ISSN:1558-3163
DOI:10.1016/j.rdc.2016.03.002