Atypically large well-differentiated hepatocellular carcinoma with extensive fatty metamorphosis: Report of a Case

A large well-differentiated hepatocellular carcinoma (HCC) with fatty change is rare, and to date only a few cases have been reported. Herein, we present a 68-year-old man who developed a well-differentiated HCC with extensive fatty metamorphosis. The patient was referred to our institute because of...

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Published inThe Journal of Medical Investigation Vol. 60; no. 3.4; pp. 267 - 271
Main Authors Utsunomiya, Tohru, Kanamoto, Mami, Morine, Yuji, Asanoma, Michihito, Shimada, Mitsuo, Iwahashi, Shuichi, Ishikawa, Daichi, Yamada, Shinichiro, Ikemoto, Tetsuya, Mori, Hiroki, Imura, Satoru, Arakawa, Yusuke
Format Journal Article
LanguageEnglish
Published Japan The University of Tokushima Faculty of Medicine 2013
Subjects
Aged
angiomyolipoma
Angiomyolipoma - diagnosis
Carcinoma, Hepatocellular - complications
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Cell Differentiation
Diagnosis, Differential
Fatty Liver - complications
Fatty Liver - pathology
fatty metamorphosis
Humans
lipomatosis
Lipomatosis - complications
Lipomatosis - pathology
Liver Neoplasms - complications
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Male
Non-alcoholic Fatty Liver Disease
well differentiated hepatocellular carcinoma
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ISSN1343-1420
1349-6867
DOI10.2152/jmi.60.267

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Summary:A large well-differentiated hepatocellular carcinoma (HCC) with fatty change is rare, and to date only a few cases have been reported. Herein, we present a 68-year-old man who developed a well-differentiated HCC with extensive fatty metamorphosis. The patient was referred to our institute because of a rapidly growing tumor in the left lobe of the liver. Ultrasonography showed a hyperechoic lesion with a peripheral hypoechoic area. Dynamic contrast-enhanced computed tomography (CT) scan in all three phases revealed the tumor which showed diffuse low attenuation with internal irregular enhancement. He underwent left lateral segmentectomy at the liver. Histological diagnosis confirmed well-differentiated HCC and the surrounding non-cancerous area was diagnosed as non-alcoholic steatohepatitis. The patient is still alive without recurrence after 17 months of follow-up. J. Med. Invest. 60: 267-271, August, 2013
ISSN:1343-1420
1349-6867
DOI:10.2152/jmi.60.267