Abnormal thyroid stimulating hormone (TSH) levels in adults following allogeneic bone marrow transplants

• Published in: Bone marrow transplantation (Basingstoke) Vol. 19; no. 10; pp. 1019 - 1022
• Main Authors: AL-FIAR, F. Z, COLWILL, R, LIPTON, J. H, FYLES, G, SPANER, D, MESSNER, H
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.05.1997
• Subjects: Abnormalities; Adolescent; Adult; Anemia, Aplastic - therapy; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Autoimmune Diseases - etiology; Biological and medical sciences; Bone marrow; Bone marrow transplantation; Bone Marrow Transplantation - adverse effects; Bone Marrow Transplantation - physiology; Bone marrow, stem cells transplantation. Graft versus host reaction; Busulfan - administration & dosage; Busulfan - adverse effects; Chemotherapy; Child; Cohort Studies; Conditioning; Cyclophosphamide - administration & dosage; Cyclophosphamide - adverse effects; Dose-Response Relationship, Radiation; Female; Graft-versus-host reaction; Humans; Hypothyroidism; Hypothyroidism - blood; Hypothyroidism - etiology; Leukemia - therapy; Lymphoma, Non-Hodgkin - therapy; Male; Medical sciences; Middle Aged; Myelodysplastic Syndromes - therapy; Radiation; Radiation dosage; Stem cell transplantation; Thyroid; Thyroid gland; Thyroid-stimulating hormone; Thyrotropin - blood; Thyroxine; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Transplantation Conditioning - adverse effects; Transplantation Conditioning - methods; Transplantation, Homologous; Transplants; Triiodothyronine; Whole-Body Irradiation - adverse effects; Endocrinopathy; Antineoplastic agent; Transfusion; Leukemia; Homograft; Hemopathy; Glycoprotein hormone; Lymphoproliferative syndrome; Bone marrow; Adult; Complication; Graft; Busulfan; Human; Thyroid diseases; Aplastic anemia; Alkanediol; TSH; Malignant hemopathy; Hypothyroidism; Non Hodgkin lymphoma; Radiotherapy; Alkanesulfonic acid; Oxazaphosphinane derivatives; Alkylating agent; Chemotherapy; Cyclophosphamide; Treatment; Adenohypophyseal hormone; Nitrogen mustard
• ISSN: 0268-3369; 1476-5365
• DOI: 10.1038/sj.bmt.1700771

Thyroid function abnormalities in 270 adult patients post-BMT are described. Various conditioning regimens were used and the effects of three TBI and one chemotherapy only based regimens are compared. The overall incidence of elevated TSH is 8.9; 3.8, 7.2 and 16.7% in those patients who received 300, 500 and 1200 cGy respectively and 11.7% in those who received BuCy conditioning. Three cases (1.1%) of clinial hypothyroidism were observed. Compensated hypothyroidism defined as an elevated TSH in the presence of normal T3, T4 levels and transient in some cases, was the most common finding. All but four cases occurred in the first 2 years after BMT. In the remaining four, three occurred in patients with chronic GVHD. The results reported here show a lower prevalence than observed in most other reviews, particularly for children. A trend was observed with increasing radiation doses. The results are not significantly different from those we observed in the BuCy regimen.