Exploiting Circular DNA

The properties of circular DNA provide an important tool for the investigation of the double helix and its interactions with ligands and proteins. Vologodskii comments on a study by Zeman et al, in which they have developed a new method to study DNA-ligand complexes.

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 95; no. 8; pp. 4092 - 4093
Main Author Vologodskii, Alexander
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences of the United States of America 14.04.1998
National Acad Sciences
National Academy of Sciences
The National Academy of Sciences
Subjects
Base Composition
Biochemistry
Bromides
Circular DNA
Commentary
Deoxyribonucleic acid
DNA
DNA, Circular - chemistry
DNA, Circular - metabolism
Electrophoresis
Experimental data
Gels
Genetic equilibrium
Ligands
Models, Chemical
Molecules
Nucleic Acid Conformation
Plasmids - chemistry
Plasmids - metabolism
Proteins
Topology
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Abstract The properties of circular DNA provide an important tool for the investigation of the double helix and its interactions with ligands and proteins. Vologodskii comments on a study by Zeman et al, in which they have developed a new method to study DNA-ligand complexes.
AbstractList The properties of circular DNA provide an important tool for the investigation of the double helix and its interactions with ligands and proteins. Vologodskii comments on a study by Zeman et al, in which they have developed a new method to study DNA-ligand complexes.
In many ways circular DNA is unique among biological macromolecules. Its properties are unusual and interesting because they are affected greatly by the topology of the molecule. The properties of circular DNA are not only an object of study, but provide an important tool for the investigation of the double helix and its interactions with ligands and proteins. The specific features of circular DNA were used to determine the bending and torsional rigidities of the double helix, its effective diameter, helical repeat of DNA in solution, and the unwinding of the double helix by bound ligands (see references in reviews in refs. All of these applications are based on the measurement of the linking number difference of closed circular DNA, which can be accomplished with remarkable accuracy and with very simple equipment. Therefore it seems hardly possible to find a new application for these well-understood properties. However, the paper by Zeman et al. published in this issue of the Proceedings proved the contrary. They have developed a new method to study DNA-ligand complexes.
Author Vologodskii, Alexander
AuthorAffiliation Department of Chemistry, New York University, New York 10003
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Cites_doi 10.1038/280294a0
10.1038/292375a0
10.1073/pnas.95.8.4327
10.1016/S0022-2836(83)80199-5
10.1146/annurev.bi.50.070181.001111
10.1073/pnas.72.11.4275
10.1016/0022-2836(84)90404-2
10.1080/07391102.1985.10507616
10.1126/science.8475384
10.1073/pnas.76.1.200
10.1093/nar/21.3.463
10.1073/pnas.72.11.4280
10.1016/0022-2836(86)90382-7
10.1073/pnas.90.11.5307
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References 9539736 - Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4327-32
Vologodskii A V (e_1_3_1_16_2) 1992
Chaires J B (e_1_3_1_14_2) 1996; 11
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  doi: 10.1038/280294a0
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  doi: 10.1073/pnas.95.8.4327
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  doi: 10.1016/S0022-2836(83)80199-5
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  doi: 10.1146/annurev.bi.50.070181.001111
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  doi: 10.1073/pnas.72.11.4275
– volume-title: Topology and Physics of Circular DNA
  year: 1992
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  contributor:
    fullname: Vologodskii A V
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  doi: 10.1016/0022-2836(84)90404-2
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Snippet The properties of circular DNA provide an important tool for the investigation of the double helix and its interactions with ligands and proteins. Vologodskii...
In many ways circular DNA is unique among biological macromolecules. Its properties are unusual and interesting because they are affected greatly by the...
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SubjectTerms Base Composition
Biochemistry
Bromides
Circular DNA
Commentary
Deoxyribonucleic acid
DNA
DNA, Circular - chemistry
DNA, Circular - metabolism
Electrophoresis
Experimental data
Gels
Genetic equilibrium
Ligands
Models, Chemical
Molecules
Nucleic Acid Conformation
Plasmids - chemistry
Plasmids - metabolism
Proteins
Topology
Title Exploiting Circular DNA
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