Relationship between chromosomal aberrations and gene expressions in the p53 pathway in chronic lymphocytic leukemia

• Published in: Balkan journal of medical genetics Vol. 23; no. 1; pp. 15 - 24
• Main Authors: Öztan, G, Aktan, M, Palanduz, S, İşsever, H, Öztürk, S, Nikerel, E, Uçur, A, Bağatir, G, Bayrak, A, Çefle, K
• Format: Journal Article
• Language: English
• Published: Sofia Sciendo 26.08.2020; De Gruyter Poland
• Subjects: Bone marrow; CDKN2A gene; Chromosome aberrations; Chronic lymphocytic leukemia; Chronic lymphocytic leukemia (CLL); Cyclin-dependent kinase 4; Cytogenetics; Fluorescence in situ hybridization; Gadd45A protein; Gene expression; Leukemia; Lymph nodes; Lymphatic leukemia; Lymphocytes B; Mcl-1 protein; MDM2 protein; Medical prognosis; Original; p53 Pathway; p53 Protein; Peripheral blood; Polymerase chain reaction; Profiler PCR (polymerase chain reaction)Array; Prognosis; Proliferating cell nuclear antigen; PTEN protein; rt2 profiler pcr (polymerase chain reaction)array; Statistical analysis

Chronic lymphocytic leukemia (CLL) is a neoplasm characterized by excessive accumulation of B lymphocytes in the peripheral blood, bone marrow and lymph nodes. We assessed the expressions of 22 genes in the p53 pathway in 30 CLL patients and 15 healthy subjects by a RT2 Profiler PCR (polymerase chai...