Marine Power on Cancer: Drugs, Lead Compounds, and Mechanisms

Worldwide, 19.3 million new cancer cases and almost 10.0 million cancer deaths occur each year. Recently, much attention has been paid to the ocean, the largest biosphere of the earth that harbors a great many different organisms and natural products, to identify novel drugs and drug candidates to f...

Full description

Saved in:
Bibliographic Details
Published inMarine drugs Vol. 19; no. 9; p. 488
Main Authors Wu, Lichuan, Ye, Ke, Jiang, Sheng, Zhou, Guangbiao
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 27.08.2021
MDPI
Subjects
Anemia
Animals
anticancer
Anticancer properties
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Antitumor activity
Apoptosis
Biological Products - chemistry
Biological Products - pharmacology
Biological Products - therapeutic use
Biology
Biosphere
Bone marrow
Brain cancer
Breast cancer
Cancer
Cell cycle
Cell division
Cyclin-dependent kinases
Cytarabine
Drug development
Drug dosages
Drug resistance
Drugs
FDA approval
Humans
Kinases
Lead compounds
Leukemia
Lung cancer
Lymphoma
Marine energy
marine environment drug
mechanisms of action
Metastases
Multiple myeloma
natural compounds
Natural products
Neoplasms
Neoplasms - drug therapy
Neutropenia
Phosphorylation
Polymerization
Proteins
Review
Seawater
Therapeutic targets
Thrombocytopenia
Tumors
natural compounds
anticancer
marine environment drug
mechanisms of action
Online AccessGet full text

Cover

More Information
Summary:Worldwide, 19.3 million new cancer cases and almost 10.0 million cancer deaths occur each year. Recently, much attention has been paid to the ocean, the largest biosphere of the earth that harbors a great many different organisms and natural products, to identify novel drugs and drug candidates to fight against malignant neoplasms. The marine compounds show potent anticancer activity in vitro and in vivo, and relatively few drugs have been approved by the U.S. Food and Drug Administration for the treatment of metastatic malignant lymphoma, breast cancer, or Hodgkin's disease. This review provides a summary of the anticancer effects and mechanisms of action of selected marine compounds, including cytarabine, eribulin, marizomib, plitidepsin, trabectedin, zalypsis, adcetris, and OKI-179. The future development of anticancer marine drugs requires innovative biochemical biology approaches and introduction of novel therapeutic targets, as well as efficient isolation and synthesis of marine-derived natural compounds and derivatives.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1660-3397
1660-3397
DOI:10.3390/md19090488