SANDRAMYCIN, A NOVEL ANTITUMOR ANTIBIOTIC PRODUCED BY A NOCARDIOIDES SP PRODUCTION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL PROPERTIES

A new antitumor antibiotic, sandramycin, was isolated from cultured broth of a Nocardioides sp. (ATCC 39419) and purified by solvent partition and column chromatography. Sandramycin, a new depsipeptide, was moderately active in vitro against Gram-positive organisms and in vivo against leukemia P388...

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Bibliographic Details
Published inJournal of antibiotics Vol. 42; no. 12; pp. 1763 - 1767
Main Authors MATSON, JAMES A., BUSH, JAMES A.
Format Journal Article
LanguageEnglish
Published Japan JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1989
Subjects
Animals
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - therapeutic use
antitumor antibiotics
Chemical Phenomena
Chemistry
gram-positive bacteria
Gram-Positive Bacteria - drug effects
Leukemia P388 - drug therapy
Mice
Microbial Sensitivity Tests
Nocardiaceae - analysis
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - therapeutic use
Quinolines - isolation & purification
Quinolines - therapeutic use
sandramycin
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Summary:A new antitumor antibiotic, sandramycin, was isolated from cultured broth of a Nocardioides sp. (ATCC 39419) and purified by solvent partition and column chromatography. Sandramycin, a new depsipeptide, was moderately active in vitro against Gram-positive organisms and in vivo against leukemia P388 in mice.
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ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.42.1763