The Yin and Yang of Innate Lymphoid Cells in Cancer

Highlights • The involvement of ILC subsets in tumor immunity has been barely investigated. • ILCs might behave either as friends or foes in cancer. • ILCs are an early source of cytokines able to affect tumor microenvironment. • Anti- or pro-tumorigenic functions of ILCs depend on the context of tu...

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Bibliographic Details
Published inImmunology letters Vol. 179; pp. 29 - 35
Main Authors Carrega, Paolo, Campana, Stefania, Bonaccorsi, Irene, Ferlazzo, Guido
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.11.2016
Subjects
Allergy and Immunology
Animals
Cancer
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - immunology
Cell Transformation, Neoplastic - metabolism
Cytokines
Cytokines - metabolism
Disease Progression
Disease Susceptibility
Humans
Immunity
Immunity, Innate
Innate lymphoid cells
Interferon-γ
Interleukin-22
Lymphocyte Activation
Lymphocyte Subsets - cytology
Lymphocyte Subsets - immunology
Lymphocyte Subsets - metabolism
Neoplasms - etiology
Neoplasms - metabolism
Neoplasms - pathology
Tertiary lymphoid structures
Tumor Microenvironment
Yin-Yang
Cytokines
Innate Lymphoid Cells
Tertiary Lymphoid Structures
Interferon-γ
Interleukin-22
Cancer
Innate lymphoid cells
Tertiary lymphoid structures
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Summary:Highlights • The involvement of ILC subsets in tumor immunity has been barely investigated. • ILCs might behave either as friends or foes in cancer. • ILCs are an early source of cytokines able to affect tumor microenvironment. • Anti- or pro-tumorigenic functions of ILCs depend on the context of tumor specificity
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
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ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2016.06.003