Risk factors for multidrug-resistant bacteremia in hospitalized cancer patients with febrile neutropenia: A cohort study

• Published in: American journal of infection control Vol. 42; no. 1; pp. 74 - 76
• Main Authors: Rosa, Regis G., MD, MS, Goldani, Luciano Z., MD, PhD, dos Santos, Rodrigo P., MD, PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 2014; Elsevier; Mosby-Year Book, Inc
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Bacteremia - epidemiology; Bacteria; Bacteria - drug effects; Bacteria - isolation & purification; Bacterial; Bacterial diseases; Bacterial sepsis; Biological and medical sciences; Cancer; Catheters; Cohort Studies; Drug resistance; Drug Resistance, Multiple, Bacterial; Epidemiology. Vaccinations; Febrile Neutropenia - complications; Febrile Neutropenia - epidemiology; Female; Fever; General aspects; Hospitalization; Human bacterial diseases; Humans; Immunocompromised host; Infection Control; Infectious Disease; Infectious diseases; Male; Medical sciences; Middle Aged; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Multivariate analysis; Neoplasms - complications; Neoplasms - therapy; Prospective Studies; Regression analysis; Risk Factors; Tertiary Care Centers; Tumors; Young Adult; Bacterial; Drug resistance; Immunocompromised host; Fever; Human; Immunopathology; Treatment resistance; Leukopenia; Check; Hemopathy; Hospitalization; Malignant tumor; Immune deficiency; Bacteremia; Infection; Prevention; Cohort study; Multiple resistance; Risk factor; Bacteriosis; Cancer; Neutropenia
• ISSN: 0196-6553; 1527-3296
• DOI: 10.1016/j.ajic.2013.06.025

We conducted a prospective cohort study in a single tertiary hospital with the aim of assessing predictors of multidrug-resistant bacteremia in 307 cases of febrile neutropenia in adult patients with cancer. On multivariate analysis using stepwise logistic regression, age ( P  = .009), duration of neutropenia ( P  = .022), and presence of an indwelling central venous catheter ( P  = .022) were associated with bloodstream infection by multidrug-resistant bacteria.