Central Nervous System Histoplasmosis: An Updated Insight

• Published in: Pathogens (Basel) Vol. 12; no. 5; p. 681
• Main Authors: Ramírez, José Antonio, Reyes-Montes, María Del Rocío, Rodríguez-Arellanes, Gabriela, Pérez-Torres, Armando, Taylor, Maria Lucia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.05.2023; MDPI
• Subjects: Abscesses; Care and treatment; Causes of; Central nervous system; Central nervous system diseases; CNS infection; Development and progression; Diagnosis; Disease; dissemination; Epidemiology; Fungal infections; Fungi; Genomes; Granulomas; H. capsulatum; histoplasmomas; Histoplasmosis; host’s CNS injuries; Immune system; Immunocompetence; Injuries; Lungs; Meningitis; Morphology; Mycosis; Nervous system; Pathogenesis; Pathogens; Phylogenetics; Spinal cord; Spinal cord injuries; Spleen; Tourism; Virulence; Mexico; Europe; histoplasmomas; host’s CNS injuries; H. capsulatum; CNS infection; dissemination
• ISSN: 2076-0817; 2076-0817
• DOI: 10.3390/pathogens12050681

Histoplasmosis is one of the systemic mycoses that can involve the Central Nervous System (CNS), and it is caused by the dimorphic ascomycete species of the complex. Once in the CNS, this pathogen causes life-threatening injuries that are associated with clinical manifestations of meningitis, focal lesions (abscesses, histoplasmomas), and spinal cord injuries. The present review provides updated data and highlights a particular vision regarding this mycosis and its causative agent, as well as its epidemiology, clinical forms, pathogenesis, diagnosis, and therapy, focusing on the CNS.