Preoperative assessment of skeletal muscle mass during magnetic resonance enterography in patients with Crohn’s disease

• Published in: Updates in surgery Vol. 73; no. 4; pp. 1419 - 1427
• Main Authors: Celentano, V., Kamil-Mustafa, L., Beable, R., Ball, C., Flashman, K. G., Jennings, Z., O’ Leary, D. P., Higginson, A., Luxton, S.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2021
• Subjects: Crohn Disease - diagnostic imaging; Crohn Disease - pathology; Crohn Disease - surgery; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Medicine; Medicine & Public Health; Original; Original Article; Postoperative Complications - diagnostic imaging; Postoperative Complications - epidemiology; Psoas Muscles - diagnostic imaging; Psoas Muscles - pathology; Retrospective Studies; Risk Factors; Sarcopenia - diagnostic imaging; Sarcopenia - pathology; Surgery; Inflammatory bowel disease; Psoas muscle; Sarcopenia; Magnetic resonance imaging; Colorectal surgery; Crohn’s disease
• ISSN: 2038-131X; 2038-3312
• DOI: 10.1007/s13304-020-00790-x

Measurement of the psoas muscle area has been applied to estimate lean muscle mass as a surrogate marker of sarcopenia, but there is a paucity of evidence regarding the influence of sarcopenia on clinical outcomes following inflammatory bowel disease surgery. The aim of this study was to evaluate the association between MRI enterography defined sarcopenia and postoperative complications in patients undergoing elective ileocaecal resection for Crohn’s disease. To obtain cross sectional area measurement of the psoas muscle, the freehand area tool was used to trace the margin of each psoas muscle at the level of L4, with the sum recorded as Total Psoas Area (TPA). The total cross sectional muscle area of the abdominal wall was recorded as Skeletal Muscle Area (SMA), while myosteatosis was measured by normalising the psoas muscle intensity with the mean intensity of the cerebrospinal fluid. The primary outcome was the incidence of 30-day postoperative complications in patients in the lowest quartile of TPA and SMA. 31 patients were included and ten patients (32.25%) developed postoperative complications within 30 days of surgery. The cut-off values for the lowest quartile for TPA were 11.93 cm 2 in men and 9.77 cm 2 in women, including a total of 8 patients (25.8%) with 5 patients in this group (62.5%) developing postoperative complications and 3 patients (37.5%) Clavien-Dindo class ≥ 3 complications. The cut-off values for the lowest quartile for SMA were 73.49 cm 2 in men and 65.85 cm 2 in women, with 4 patients out of 8 (50%) developing postoperative complications. Psoas muscle cross sectional area and skeletal mass area can be estimated on Magnetic Resonance Enterography as surrogate markers of sarcopenia with high inter-observer agreement.