Diversity of potentially exploitable pharmacological activities of the highly prized edible medicinal fungus Antrodia camphorata

• Published in: Applied microbiology and biotechnology Vol. 103; no. 19; pp. 7843 - 7867
• Main Authors: Wang, Caicheng, Zhang, Weiwei, Wong, Jack Ho, Ng, Tzibun, Ye, Xiujuan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2019; Springer; Springer Nature B.V
• Subjects: Anticancer properties; Antidiabetics; Antihypertensives; Antitumor activity; Antrodia - classification; Antrodia - genetics; Antrodia - metabolism; Apoptosis; Basidiocarps; Biological Products - metabolism; Biomedical and Life Sciences; Biomedical materials; Biotechnology; Bladder; Breast; Cancer; Care and treatment; Cell cycle; Colorectal cancer; Dermatitis; Diabetes mellitus; Fungi; Genetic Variation; Glioblastoma; Gliomas; Immunoregulation; Ingredients; Ionizing radiation; Kinases; Laboratories; Leukemia; Life Sciences; Liver cancer; Lung cancer; Lungs; Lymphoma; Lymphomas; Melanoma; Microbial Genetics and Genomics; Microbiology; Mini-Review; Mushrooms; Neuroblastoma; Neuroprotection; Oral cancer; Pancreas; Pharmacology; Prostate; Proteins; Taiwan; Technology, Pharmaceutical - methods; Virology; Wound healing; Taiwan; Canada; China; Neuroprotective; Hepatoprotective; Anticancer; Antileukemia; Antiinflammatory; Antrodia camphorata
• ISSN: 0175-7598; 1432-0614
• DOI: 10.1007/s00253-019-10016-9

Antrodia camphorata , also known as A. cinnamomea , is a precious medicinal basidiomycete fungus endemic to Taiwan. This article summarizes the recent advances in research on the multifarious pharmacological effects of A. camphorata . The mushroom exhibits anticancer activity toward a large variety of cancers including breast, cervical, ovarian, prostate, bladder, colorectal, pancreatic, liver, and lung cancers; melanoma; leukemia; lymphoma; neuroblastoma; and glioblastoma. Other activities encompass antiinflammatory, antiatopic dermatitis, anticachexia, immunoregulatory, antiobesity, antidiabetic, antihyperlipidemic, antiatherosclerotic, antihypertensive, antiplatelet, antioxidative, antiphotodamaging, hepatoprotective, renoprotective, neuroprotective, testis protecting, antiasthmatic, osteogenic, osteoprotective, antiviral, antibacterial, and wound healing activities. This review aims to provide a reference for further development and utilization of this highly prized mushroom.