potential strategy for high-grade gliomas: combination treatment with lithium chloride and BmK CT
Therapies for high-grade gliomas (HHG) that have strong tendency of infiltration and resistance to chemotherapies are currently unavailable. Here, we report that lower-dose combination therapy of Buthus martensii Karsch (BmK) CT, a type of scorpion toxin peptide, and LiCl, clinically used as mood st...
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| Published in | Biotechnology letters Vol. 34; no. 1; pp. 9 - 17 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Dordrecht
Springer-Verlag
2012
Springer Netherlands Springer Springer Nature B.V |
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| Abstract | Therapies for high-grade gliomas (HHG) that have strong tendency of infiltration and resistance to chemotherapies are currently unavailable. Here, we report that lower-dose combination therapy of Buthus martensii Karsch (BmK) CT, a type of scorpion toxin peptide, and LiCl, clinically used as mood stabilizer, could synergistically inhibit the migration, invasion and proliferation of C6 glioma cells. The decreased invasiveness of C6 glioma cells was accompanied by inhibited activation, catalytic activity and/or expression of matrix metalloproteinase-2. Moreover, TOPfalsh luciferase reporter and immunofluorescence staining showed altered localization pattern of β-catenin at the leading edge of 2D scratch. Our results suggested that the combination treatment of lithium and BmK CT may constitute a novel and potential strategy for HHG therapy. |
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| AbstractList | Therapies for high-grade gliomas (HHG) that have strong tendency of infiltration and resistance to chemotherapies are currently unavailable. Here, we report that lower-dose combination therapy of Buthus martensii Karsch (BmK) CT, a type of scorpion toxin peptide, and LiCl, clinically used as mood stabilizer, could synergistically inhibit the migration, invasion and proliferation of C6 glioma cells. The decreased invasiveness of C6 glioma cells was accompanied by inhibited activation, catalytic activity and/or expression of matrix metalloproteinase-2. Moreover, TOPfalsh luciferase reporter and immunofluorescence staining showed altered localization pattern of β-catenin at the leading edge of 2D scratch. Our results suggested that the combination treatment of lithium and BmK CT may constitute a novel and potential strategy for HHG therapy. Therapies for high-grade gliomas (HHG) that have strong tendency of infiltration and resistance to chemotherapies are currently unavailable. Here, we report that lower-dose combination therapy of Buthus martensii Karsch (BmK) CT, a type of scorpion toxin peptide, and LiCl, clinically used as mood stabilizer, could synergistically inhibit the migration, invasion and proliferation of C6 glioma cells. The decreased invasiveness of C6 glioma cells was accompanied by inhibited activation, catalytic activity and/or expression of matrix metalloproteinase-2. Moreover, TOPfalsh luciferase reporter and immunofluorescence staining showed altered localization pattern of β-catenin at the leading edge of 2D scratch. Our results suggested that the combination treatment of lithium and BmK CT may constitute a novel and potential strategy for HHG therapy.[PUBLICATION ABSTRACT] Therapies for high-grade gliomas (HHG) that have strong tendency of infiltration and resistance to chemotherapies are currently unavailable. Here, we report that lower-dose combination therapy of Buthus martensii Karsch (BmK) CT, a type of scorpion toxin peptide, and LiCl, clinically used as mood stabilizer, could synergistically inhibit the migration, invasion and proliferation of C6 glioma cells. The decreased invasiveness of C6 glioma cells was accompanied by inhibited activation, catalytic activity and/or expression of matrix metalloproteinase-2. Moreover, TOPfalsh luciferase reporter and immunofluorescence staining showed altered localization pattern of beta -catenin at the leading edge of 2D scratch. Our results suggested that the combination treatment of lithium and BmK CT may constitute a novel and potential strategy for HHG therapy. Therapies for high-grade gliomas (HHG) that have strong tendency of infiltration and resistance to chemotherapies are currently unavailable. Here, we report that lower-dose combination therapy of Buthus martensii Karsch ( Bm K) CT, a type of scorpion toxin peptide, and LiCl, clinically used as mood stabilizer, could synergistically inhibit the migration, invasion and proliferation of C6 glioma cells. The decreased invasiveness of C6 glioma cells was accompanied by inhibited activation, catalytic activity and/or expression of matrix metalloproteinase-2. Moreover, TOPfalsh luciferase reporter and immunofluorescence staining showed altered localization pattern of β-catenin at the leading edge of 2D scratch. Our results suggested that the combination treatment of lithium and Bm K CT may constitute a novel and potential strategy for HHG therapy. |
| Author | Zheng, Shuhua Zhang, Zhiyun Huang, Rui Zheng, Yali An, Na Liang, Aihua Fu, Yuejun |
| Author_xml | – sequence: 1 fullname: Fu, Yuejun – sequence: 2 fullname: Zheng, Shuhua – sequence: 3 fullname: Huang, Rui – sequence: 4 fullname: An, Na – sequence: 5 fullname: Zheng, Yali – sequence: 6 fullname: Zhang, Zhiyun – sequence: 7 fullname: Liang, Aihua |
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| CitedBy_id | crossref_primary_10_1007_s10529_017_2365_7 crossref_primary_10_1155_2013_958797 crossref_primary_10_3892_mmr_2017_6284 crossref_primary_10_1007_s10616_014_9768_2 crossref_primary_10_1097_IGC_0b013e31827cfecb crossref_primary_10_1016_j_peptides_2019_02_009 crossref_primary_10_3389_fphar_2020_01132 crossref_primary_10_7314_APJCP_2015_16_7_2807 crossref_primary_10_1016_j_jocn_2012_07_002 crossref_primary_10_1016_j_jchromb_2013_12_023 |
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| Keywords | Karsch CT β-Catenin Glioma Lithium chloride Matrix metalloproteinase-2 Peptidases Treatment Enzyme Buthus martensii Karsch CT Hydrolases Metalloendopeptidases Gelatinase A |
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| Title | potential strategy for high-grade gliomas: combination treatment with lithium chloride and BmK CT |
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