Banff 07 Classification of Renal Allograft Pathology: Updates and Future Directions

• Published in: American journal of transplantation Vol. 8; no. 4; pp. 753 - 760
• Main Authors: Solez, K., Colvin, R. B., Racusen, L. C., Haas, M., Sis, B., Mengel, M., Halloran, P. F., Baldwin, W., Banfi, G., Collins, A. B., Cosio, F., David, D. S. R., Drachenberg, C., Einecke, G., Fogo, A. B., Gibson, I. W., Glotz, D., Iskandar, S. S., Kraus, E., Lerut, E., Mannon, R. B., Mihatsch, M., Nankivell, B. J., Nickeleit, V., Papadimitriou, J. C., Randhawa, P., Regele, H., Renaudin, K., Roberts, I., Seron, D., Smith, R. N., Valente, M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2008; Blackwell
• Subjects: Acute allograft rejection; acute cellular rejection; acute rejection; allograft rejection; antibody‐mediated rejection; Banff; Banff lesions; Banff schema; Biological and medical sciences; Biopsy; chronic allograft nephropathy; chronic allograft rejection; classification; Clinical Trials as Topic; Complement C4b - analysis; GeneChip; genomic markers; Graft Rejection - pathology; Graft Rejection - prevention & control; Graft Survival; Humans; Immunosuppressive Agents - therapeutic use; Kidney Transplantation - immunology; Kidney Transplantation - pathology; Medical sciences; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Peptide Fragments - analysis; Renal failure; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Transplantation, Homologous; Graft(material); Chronic renal failure; Acute allograft rejection; chronic allograft nephropathy; Genomics; Homograft; Biological marker; Transplantation; Banff classification; Homotransplantation; GeneChip; Kidney; Banff schema; Surgery; antibody- mediated rejection; Graft; Genetics; genomic markers; Cell; Banff lesions; Kidney disease; Banff; Urinary system disease; Antibody; Acute; acute cellular rejection; classification; allograft rejection; Rejection; Anatomic pathology; Chronic; Nephropathy; Treatment; Urinary system; acute rejection; chronic allograft rejection; Renal failure; Lesion; Genome
• ISSN: 1600-6135; 1600-6143
• DOI: 10.1111/j.1600-6143.2008.02159.x

The 9th Banff Conference on Allograft Pathology was held in La Coruna, Spain on June 23–29, 2007. A total of 235 pathologists, clinicians and scientists met to address unsolved issues in transplantation and adapt the Banff schema for renal allograft rejection in response to emerging data and technologies. The outcome of the consensus discussions on renal pathology is provided in this article. Major updates from the 2007 Banff Conference were: inclusion of peritubular capillaritis grading, C4d scoring, interpretation of C4d deposition without morphological evidence of active rejection, application of the Banff criteria to zero‐time and protocol biopsies and introduction of a new scoring for total interstitial inflammation (ti‐score). In addition, emerging research data led to the establishment of collaborative working groups addressing issues like isolated ‘v’ lesion and incorporation of omics‐technologies, paving the way for future combination of graft biopsy and molecular parameters within the Banff process. The Ninth Banff Conference on Allograft Pathology held in La Coruna, Spain June 23‐29, 2007 resulted in new developments pertaining to C4d staining, peritubular capillaritis, protocol biopsies, lesion scoring, and eventual incorporation of “omics” technologies into kidney transplant rejection diagnosis.