TRYPANOCIDAL ACTION OF p‐BIGUANIDOACETOPHENONE AMIDINOHYDRAZONE

p‐Biguanidoacetophenone amidinohydrazone, given in single doses, can cure mice infected with an old laboratory strain of Trypanosoma rhodesiense, but it has only slight action on more recently isolated strains. Trypanosomes which are resistant to stilbamidine are resistant to this compound also. App...

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Bibliographic Details
Published inBritish Journal of Pharmacology Vol. 19; no. 2; pp. 324 - 325
Main Author HAWKING, F.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.10.1962
Subjects
Acetophenones
Animals
Guanidine
Guanidines
Mice
Old Medline
Pentamidine
Trypanocidal Agents
Trypanosoma
Trypanosoma brucei brucei
Trypanosoma brucei rhodesiense
Trypanosomiasis
Trypanosomiasis, African
GUANIDINES
TRYPANCSOMIASIS
ACETOPHENONES
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Summary:p‐Biguanidoacetophenone amidinohydrazone, given in single doses, can cure mice infected with an old laboratory strain of Trypanosoma rhodesiense, but it has only slight action on more recently isolated strains. Trypanosomes which are resistant to stilbamidine are resistant to this compound also. Apparently its trypanocidal action is similar to that of the diamidine series of trypanocidal compounds.
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ISSN:0366-0826
1476-5381
DOI:10.1111/j.1476-5381.1962.tb01196.x