Cease-fire at the leading edge: New perspectives on actin filament branching, debranching, and cross-linking

Membrane protrusion at the leading edge of migrating cells is driven by the polymerization of actin. Recent studies using advanced imaging techniques raised a lively controversy about the morphology of these filaments; however, common ground between the two sides now appears to have been found. Here...

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Bibliographic Details
Published inCytoskeleton (Hoboken, N.J.) Vol. 68; no. 11; pp. 596 - 602
Main Authors Ydenberg, Casey A., Smith, Benjamin A., Breitsprecher, Dennis, Gelles, Jeff, Goode, Bruce L.
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.11.2011
Subjects
actin
Actin Cytoskeleton - metabolism
Arp2/3 complex
cell motility
Cell Movement - physiology
Cytoskeleton - metabolism
electron microscopy
formin
Humans
lamellipodium
Microfilament Proteins - metabolism
VASP
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Summary:Membrane protrusion at the leading edge of migrating cells is driven by the polymerization of actin. Recent studies using advanced imaging techniques raised a lively controversy about the morphology of these filaments; however, common ground between the two sides now appears to have been found. Here we discuss how the controversy has led to a deeper consideration of the architecture of actin networks underlying cell migration, and has helped define new challenges that lie ahead. © 2011 Wiley Periodicals, Inc.
Bibliography:Monitoring Editor: Roberto Dominguez
ArticleID:CM20543
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ark:/67375/WNG-RQGG494S-7
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1949-3584
1949-3592
DOI:10.1002/cm.20543