Evaluation of anti-apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide
Objective:To evaluate the anti-apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid,a-tocopherol acetate,citric acid,salicylic acid,and estimate H2O2induced apoptosis in renal cell carcinoma cells.Methods:The intracellular antioxidant potency of antioxidants was inv...
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| Published in | Asian Pacific journal of tropical biomedicine Vol. 1; no. 1; pp. 57 - 63 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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China
Elsevier B.V
2011
Asian Pacific Tropical Medicine Press |
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| Abstract | Objective:To evaluate the anti-apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid,a-tocopherol acetate,citric acid,salicylic acid,and estimate H2O2induced apoptosis in renal cell carcinoma cells.Methods:The intracellular antioxidant potency of antioxidants was investigated.H2O-2-induced apoptosis in RCC-26 was assayed with the following parameters:cell viability（%apoptosis）,nucleosomal damage and DNA fragmentation, bcl-2 levels and flow cytometery analysis（ROS production evaluation）.Results:Ine anticancer properties of antioxidants such as ascorbic acid,a- tocopherol acetate,citric acid,salicylic acid with perdurable responses were investigated.It was observed that these antioxidants had protective effect（anti-apoptotic activity） against hydrogen peroxide（H2O2） in renal cell carcinoma（RCC-26） cell line.Conclusions:This study reveals and proves the anticancer properties.However,in cancer cell lines anti-apoptotic activity can indirectly reflect the cancer promoter activity through radicals scavenging,and significantly protect nucleus and bcl-2. |
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| AbstractList | Objective:To evaluate the anti-apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid,a-tocopherol acetate,citric acid,salicylic acid,and estimate H2O2induced apoptosis in renal cell carcinoma cells.Methods:The intracellular antioxidant potency of antioxidants was investigated.H2O-2-induced apoptosis in RCC-26 was assayed with the following parameters:cell viability（%apoptosis）,nucleosomal damage and DNA fragmentation, bcl-2 levels and flow cytometery analysis（ROS production evaluation）.Results:Ine anticancer properties of antioxidants such as ascorbic acid,a- tocopherol acetate,citric acid,salicylic acid with perdurable responses were investigated.It was observed that these antioxidants had protective effect（anti-apoptotic activity） against hydrogen peroxide（H2O2） in renal cell carcinoma（RCC-26） cell line.Conclusions:This study reveals and proves the anticancer properties.However,in cancer cell lines anti-apoptotic activity can indirectly reflect the cancer promoter activity through radicals scavenging,and significantly protect nucleus and bcl-2. To evaluate the anti–apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid, α -tocopherol acetate, citric acid, salicylic acid, and estimate H 2O 2-induced apoptosis in renal cell carcinoma cells. The intracellular antioxidant potency of antioxidants was investigated. H 2O 2-induced apoptosis in RCC-26 was assayed with the following parameters: cell viability (% apoptosis), nucleosomal damage and DNA fragmentation, bcl-2 levels and flow cytometery analysis (ROS production evaluation). The anticancer properties of antioxidants such as ascorbic acid, α – tocopherol acetate, citric acid, salicylic acid with perdurable responses were investigated. It was observed that these antioxidants had protective effect (anti–apoptotic activity) against hydrogen peroxide (H 2O 2) in renal cell carcinoma (RCC-26) cell line. This study reveals and proves the anticancer properties. However, in cancer cell lines anti–apoptotic activity can indirectly reflect the cancer promoter activity through radicals scavenging, and significantly protect nucleus and bcl-2. To evaluate the anti-apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid,α-tocopherol acetate, citric acid, salicylic acid, and estimate H2O2-induced apoptosis in renal cell carcinoma cells. The intracellular antioxidant potency of antioxidants was investigated. H2O2-induced apoptosis in RCC-26 was assayed with the following parameters: cell viability (% apoptosis), nucleosomal damage and DNA fragmentation, bcl-2 levels and flow cytometery analysis (ROS production evaluation). The anticancer properties of antioxidants such as ascorbic acid, α-tocopherol acetate, citric acid, salicylic acid with perdurable responses were investigated. It was observed that these antioxidants had protective effect (anti-apoptotic activity) against hydrogen peroxide (H2O2) in renal cell carcinoma (RCC-26) cell line. This study reveals and proves the anticancer properties. However, in cancer cell lines anti-apoptotic activity can indirectly reflect the cancer promoter activity through radicals scavenging, and significantly protect nucleus and bcl-2. |
| Author | Garg Neeraj K Mangal Sharad Sahu Tejram Mehta Abhinav Vyas Suresh P Tyagi Rajeev K |
| AuthorAffiliation | Department of Pharmaceutical Sciences,Dr.H.S.Gour University Biologie et genetiqjue du paludisme,Institut Pasteur,28 Rue Du Docteur Roux,75724 Paris Cedex 15,France Biomedical Parasitology Unit,Pasteur Institute |
| AuthorAffiliation_xml | – name: 1 Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar, (M.P.), India – name: 2 Biologie et génétiqjue du paludisme, Institut Pasteur, 28 Rue Du Docteur Roux, 75724 Paris Cedex 15, France – name: 3 Biomedical Parasitology Unit, Pasteur Institute, 25-28 Rue Du Dr Roux, 75724 Paris Cedex 15, France |
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| Copyright | 2011 Asian Pacific Tropical Biomedical Magazine 2011 by the Asian Pacific Journal of Tropical Biomedicine. All rights reserved. 2011 |
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| Keywords | Antioxidants Hydrogen peroxide RCC-26 Anticancer ROS Apoptosis |
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| Notes | Garg Neeraj K;Mangal Sharad;Sahu Tejram;Mehta Abhinav;Vyas Suresh P;Tyagi Rajeev K;Department of Pharmaceutical Sciences,Dr.H.S.Gour University;Biologie et genetiqjue du paludisme,Institut Pasteur;Biomedical Parasitology Unit,Pasteur Institute |
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| Snippet | Objective:To evaluate the anti-apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid,a-tocopherol acetate,citric... To evaluate the anti–apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid, α -tocopherol acetate, citric acid, salicylic... To evaluate the anti-apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid,α-tocopherol acetate, citric acid, salicylic acid,... |
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| SubjectTerms | Anticancer Antioxidants Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Carcinoma, Renal Cell Cell Line, Tumor Cell Survival - drug effects DNA Fragmentation - drug effects Humans Hydrogen Hydrogen peroxide Hydrogen Peroxide - toxicity Original Oxidative Stress - drug effects peroxide RCC-26 Reactive Oxygen Species - analysis Reactive Oxygen Species - metabolism ROS Vitamins - pharmacology |
| Title | Evaluation of anti-apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide |
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