Challenges in the clinical application of whole-genome sequencing

• Published in: The Lancet (British edition) Vol. 375; no. 9727; pp. 1749 - 1751
• Main Authors: Ormond, Kelly E, MSc, Wheeler, Matthew T, MD, Hudgins, Louanne, Prof, Klein, Teri E, PhD, Butte, Atul J, MD, Altman, Russ B, Prof, Ashley, Euan A, MRCP, Greely, Henry T, Prof
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.05.2010; Elsevier Limited
• Subjects: Family medical history; Genes; Genetic counseling; Genetic Counseling - economics; Genetic Predisposition to Disease; Genetic Testing - economics; Genetics; Genome, Human; Genome-Wide Association Study - economics; Humans; Internal Medicine; Professional-Patient Relations

Since whole-genome sequencing will show that every patient has an above-average risk for some disorders, and for having children with some genetic diseases, every patient could face some negative social consequences from those risks, whether in insurance, employment, stigma, or otherwise. [...] spec...