Challenges in the clinical application of whole-genome sequencing

Since whole-genome sequencing will show that every patient has an above-average risk for some disorders, and for having children with some genetic diseases, every patient could face some negative social consequences from those risks, whether in insurance, employment, stigma, or otherwise. [...] spec...

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Published inThe Lancet (British edition) Vol. 375; no. 9727; pp. 1749 - 1751
Main Authors Ormond, Kelly E, MSc, Wheeler, Matthew T, MD, Hudgins, Louanne, Prof, Klein, Teri E, PhD, Butte, Atul J, MD, Altman, Russ B, Prof, Ashley, Euan A, MRCP, Greely, Henry T, Prof
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 15.05.2010
Elsevier Limited
Subjects
Family medical history
Genes
Genetic counseling
Genetic Counseling - economics
Genetic Predisposition to Disease
Genetic Testing - economics
Genetics
Genome, Human
Genome-Wide Association Study - economics
Humans
Internal Medicine
Professional-Patient Relations
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Summary:Since whole-genome sequencing will show that every patient has an above-average risk for some disorders, and for having children with some genetic diseases, every patient could face some negative social consequences from those risks, whether in insurance, employment, stigma, or otherwise. [...] specific sequencing methods will have limitations that need to be understood. [...] interpretation of a whole-genome sequence requires good information about every known genetic disease and pharmacological risk.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(10)60599-5