Challenges in the clinical application of whole-genome sequencing
Since whole-genome sequencing will show that every patient has an above-average risk for some disorders, and for having children with some genetic diseases, every patient could face some negative social consequences from those risks, whether in insurance, employment, stigma, or otherwise. [...] spec...
Saved in:
| Published in | The Lancet (British edition) Vol. 375; no. 9727; pp. 1749 - 1751 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
15.05.2010
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Since whole-genome sequencing will show that every patient has an above-average risk for some disorders, and for having children with some genetic diseases, every patient could face some negative social consequences from those risks, whether in insurance, employment, stigma, or otherwise. [...] specific sequencing methods will have limitations that need to be understood. [...] interpretation of a whole-genome sequence requires good information about every known genetic disease and pharmacological risk. |
|---|---|
| AbstractList | Since whole-genome sequencing will show that every patient has an above-average risk for some disorders, and for having children with some genetic diseases, every patient could face some negative social consequences from those risks, whether in insurance, employment, stigma, or otherwise. [...] specific sequencing methods will have limitations that need to be understood. [...] interpretation of a whole-genome sequence requires good information about every known genetic disease and pharmacological risk. |
| Author | Ormond, Kelly E, MSc Butte, Atul J, MD Hudgins, Louanne, Prof Ashley, Euan A, MRCP Klein, Teri E, PhD Altman, Russ B, Prof Greely, Henry T, Prof Wheeler, Matthew T, MD |
| Author_xml | – sequence: 1 fullname: Ormond, Kelly E, MSc – sequence: 2 fullname: Wheeler, Matthew T, MD – sequence: 3 fullname: Hudgins, Louanne, Prof – sequence: 4 fullname: Klein, Teri E, PhD – sequence: 5 fullname: Butte, Atul J, MD – sequence: 6 fullname: Altman, Russ B, Prof – sequence: 7 fullname: Ashley, Euan A, MRCP – sequence: 8 fullname: Greely, Henry T, Prof |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20434765$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkctOwzAQRS0EgvL4BFDEBlgExq-k3oBQxUtCYgFI7KzEmbYG1y5xCuLvcVvogg0rj-zjO-PjbbLug0dC9imcUqDF2SNQAXlR8uKYwkkBUqlcrpEeFaXIpShf1klvhWyR7RhfAUAkcJNsMRBclIXskcvBuHIO_QhjZn3WjTEzznprKpdV06lLRWeDz8Iw-xwHh_kIfZhgFvF9ht5YP9olG8PKRdz7WXfI8_XV0-A2v3-4uRtc3udGUtbl2BSoDANOBSps1DCNpSQ3lVGpqJta1TVI2ggELPtKMDAS01FdozSKMb5Djpa50zak3rHTExsNOld5DLOoS84pCOBlIg__kK9h1vo0nGb9PpeSs36C5BIybYixxaGetnZStV-agp4b1gvDeq5vvrUwrGW6d_ATPqsn2Kxu_SpNwMUSwCTjw2Kro7FJFTa2RdPpJth_W5z_Sfj9kjf8wrh6DNWRaViGzDMoLBIk_wamxaBr |
| CODEN | LANCAO |
| CitedBy_id | crossref_primary_10_1002_ajmg_a_35328 crossref_primary_10_1371_journal_pone_0027894 crossref_primary_10_12688_f1000research_13601_1 crossref_primary_10_1007_s10897_017_0104_9 crossref_primary_10_1038_ejhg_2014_298 crossref_primary_10_1177_2515841420954592 crossref_primary_10_1002_jgc4_1098 crossref_primary_10_1016_j_jpeds_2013_07_028 crossref_primary_10_1038_ejhg_2011_123 crossref_primary_10_1373_clinchem_2013_209213 crossref_primary_10_1007_s10897_016_9968_3 crossref_primary_10_1002_jgc4_1653 crossref_primary_10_3904_kjim_2015_30_2_148 crossref_primary_10_5363_tits_16_7_84 crossref_primary_10_1111_cge_12299 crossref_primary_10_1007_s10897_013_9670_7 crossref_primary_10_3322_caac_20128 crossref_primary_10_1136_amiajnl_2011_000621 crossref_primary_10_1016_j_tig_2012_11_004 crossref_primary_10_4045_tidsskr_12_0078 crossref_primary_10_1002_humu_22370 crossref_primary_10_3390_genes13101752 crossref_primary_10_1111_apa_12601 crossref_primary_10_1002_hast_50 crossref_primary_10_4065_mcp_2011_0190 crossref_primary_10_1101_cshperspect_a036582 crossref_primary_10_2217_pme_13_104 crossref_primary_10_1007_s10897_016_9957_6 crossref_primary_10_1111_j_1748_720X_2011_00626_x crossref_primary_10_1136_jmedgenet_2019_106410 crossref_primary_10_1002_cpt_411 crossref_primary_10_3390_ijms18020361 crossref_primary_10_1177_2158244019835936 crossref_primary_10_1542_peds_2022_058222 crossref_primary_10_1016_j_tig_2013_08_005 crossref_primary_10_1093_eurheartj_ehs112 crossref_primary_10_1038_ejhg_2012_297 crossref_primary_10_1097_PPO_0b013e3182610e38 crossref_primary_10_1371_journal_pone_0064824 crossref_primary_10_1097_NPT_0000000000000066 crossref_primary_10_1111_jlme_12151 crossref_primary_10_1007_s10897_013_9641_z crossref_primary_10_11144_Javeriana_upsy17_4_fpva crossref_primary_10_1016_j_jbi_2011_02_003 crossref_primary_10_1038_ejhg_2014_279 crossref_primary_10_3389_fimmu_2021_780134 crossref_primary_10_1080_08989621_2011_575033 crossref_primary_10_1080_15265161_2020_1867933 crossref_primary_10_1016_j_pcad_2012_04_006 crossref_primary_10_1136_bmj_l789 crossref_primary_10_1038_s41431_018_0332_y crossref_primary_10_1002_humu_21518 crossref_primary_10_1126_scitranslmed_3002243 crossref_primary_10_1002_jso_23712 crossref_primary_10_1007_s10897_014_9709_4 crossref_primary_10_1007_s10545_011_9326_4 crossref_primary_10_1007_s40142_015_0075_9 crossref_primary_10_1016_j_socscimed_2018_08_015 crossref_primary_10_1002_ajmg_a_37256 crossref_primary_10_1016_j_compbiomed_2014_07_001 crossref_primary_10_1093_bioadv_vbab045 crossref_primary_10_1080_14636778_2015_1131116 crossref_primary_10_1007_s10897_011_9424_3 crossref_primary_10_1111_jlme_12160 crossref_primary_10_1016_j_molimm_2012_08_016 crossref_primary_10_1038_ejhg_2014_260 crossref_primary_10_2522_ptj_20150112 crossref_primary_10_1038_nrg3031 crossref_primary_10_12688_f1000research_12850_2 crossref_primary_10_12688_f1000research_12850_1 crossref_primary_10_1212_CPJ_0b013e31823cd13c crossref_primary_10_1038_ejhg_2012_271 crossref_primary_10_1111_j_1748_720X_2012_00699_x crossref_primary_10_1097_TP_0b013e31824db954 crossref_primary_10_1371_journal_pone_0019166 crossref_primary_10_1016_S1474_4422_11_70175_2 crossref_primary_10_1212_01_CON_0000396960_90316_8e crossref_primary_10_1007_s11673_013_9429_8 crossref_primary_10_1093_bioinformatics_btr029 crossref_primary_10_2217_pme_15_44 crossref_primary_10_1007_s12687_014_0189_x crossref_primary_10_1002_pd_4968 crossref_primary_10_1161_CIRCULATIONAHA_111_027300 crossref_primary_10_1111_j_1399_0004_2012_01872_x crossref_primary_10_3390_laws5030036 crossref_primary_10_2217_pgs_13_119 crossref_primary_10_3389_fmed_2021_784455 crossref_primary_10_1002_humu_22748 crossref_primary_10_1007_s12687_014_0194_0 crossref_primary_10_1007_s10897_013_9611_5 crossref_primary_10_1007_s10897_014_9695_6 crossref_primary_10_3893_jjaam_22_85 crossref_primary_10_2217_pme_12_23 crossref_primary_10_1111_jnu_12207 crossref_primary_10_1542_peds_2018_1099B crossref_primary_10_1002_jgc4_1182 crossref_primary_10_1101_gr_127845_111 crossref_primary_10_1002_hast_328 crossref_primary_10_1093_annonc_mdq668 crossref_primary_10_1016_j_ccc_2010_12_012 crossref_primary_10_1136_medethics_2016_103564 crossref_primary_10_1007_s40142_013_0009_3 crossref_primary_10_1053_j_seminoncol_2019_05_001 crossref_primary_10_1002_widm_54 crossref_primary_10_1186_gm347 crossref_primary_10_1007_s10897_011_9415_4 crossref_primary_10_1111_j_1440_1754_2011_02168_x crossref_primary_10_1016_S0140_6736_10_60598_3 crossref_primary_10_1097_ACM_0b013e3182223acf crossref_primary_10_1007_s10897_011_9472_8 crossref_primary_10_2217_pgs_13_76 crossref_primary_10_1016_j_atg_2015_02_005 crossref_primary_10_4078_jrd_2013_20_6_348 crossref_primary_10_1111_j_1540_8183_2010_00590_x crossref_primary_10_1111_j_1440_1754_2011_02204_x crossref_primary_10_1200_JCO_2012_45_2789 crossref_primary_10_1139_gen_2015_0145 crossref_primary_10_1161_01_cir_0000437913_98912_1d crossref_primary_10_1007_s10897_014_9794_4 crossref_primary_10_1007_s10897_014_9737_0 crossref_primary_10_1016_j_molonc_2013_04_008 crossref_primary_10_1007_s00439_011_1028_3 crossref_primary_10_1186_gm362 crossref_primary_10_1038_ejhg_2013_73 crossref_primary_10_1186_1755_8794_5_31 crossref_primary_10_2217_pme_11_33 crossref_primary_10_1016_j_pec_2019_08_018 crossref_primary_10_1007_s00392_021_01942_8 crossref_primary_10_1016_j_jpainsymman_2010_08_009 crossref_primary_10_1007_s00439_014_1484_7 crossref_primary_10_1002_humu_21555 crossref_primary_10_1016_j_molmed_2015_01_002 crossref_primary_10_1111_j_1365_2044_2011_06918_x crossref_primary_10_1016_j_jmoldx_2015_03_001 crossref_primary_10_1038_clpt_2012_49 crossref_primary_10_1038_nrgastro_2010_170 crossref_primary_10_1371_journal_pone_0023182 crossref_primary_10_1007_s12038_017_9686_5 crossref_primary_10_1089_gtmb_2015_0061 crossref_primary_10_1021_jp4119138 crossref_primary_10_1017_S0016672315000178 crossref_primary_10_1016_j_labcli_2015_01_002 crossref_primary_10_1016_j_numecd_2012_04_010 crossref_primary_10_1097_PAT_0b013e32834f4d69 crossref_primary_10_1007_s00399_012_0230_x crossref_primary_10_1371_journal_pgen_1002280 crossref_primary_10_3389_fgene_2023_1258083 crossref_primary_10_1007_s12687_016_0260_x crossref_primary_10_1016_j_ymgmr_2023_100972 crossref_primary_10_1007_s10897_018_0216_x crossref_primary_10_1051_medsci_2010266_7655 crossref_primary_10_1002_pd_4647 |
| Cites_doi | 10.1016/S0140-6736(10)60452-7 10.1001/jama.296.2.212 10.1111/j.1467-9280.2006.01720.x |
| ContentType | Journal Article |
| Copyright | Elsevier Ltd 2010 Elsevier Ltd Copyright Elsevier Limited May 15-May 21, 2010 |
| Copyright_xml | – notice: Elsevier Ltd – notice: 2010 Elsevier Ltd – notice: Copyright Elsevier Limited May 15-May 21, 2010 |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 0TT 0TZ 0U~ 3V. 7QL 7QP 7RV 7TK 7U7 7U9 7X7 7XB 88A 88C 88E 88G 88I 8AF 8AO 8C1 8C2 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AFKRA AN0 ASE AZQEC BBNVY BEC BENPR BHPHI C1K CCPQU DWQXO FPQ FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K6X K9- K9. KB0 KB~ LK8 M0R M0S M0T M1P M2M M2O M2P M7N M7P MBDVC NAPCQ PQEST PQQKQ PQUKI PSYQQ Q9U S0X 7X8 |
| DOI | 10.1016/S0140-6736(10)60599-5 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef News PRO Pharma and Biotech Premium PRO Global News & ABI/Inform Professional ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Nursing & Allied Health Database (ProQuest) Neurosciences Abstracts Toxicology Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Healthcare Administration Database (Alumni) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection Public Health Database (Proquest) Lancet Titles ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest Central British Nursing Database British Nursing Index ProQuest Central Essentials Biological Science Collection eLibrary ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea British Nursing Index (BNI) (1985 to Present) Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection British Nursing Index Consumer Health Database (Alumni Edition) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) ProQuest Newsstand Professional ProQuest Biological Science Collection Family Health Database (Proquest) Health & Medical Collection (Alumni Edition) Healthcare Administration Database Medical Database Psychology Database ProQuest research library Science Database (ProQuest) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Research Library (Corporate) Nursing & Allied Health Premium ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest One Psychology ProQuest Central Basic SIRS Editorial MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest One Psychology Research Library Prep ProQuest Central Student News PRO ProQuest Central Essentials Lancet Titles elibrary ProQuest AP Science SciTech Premium Collection Environmental Sciences and Pollution Management Global News & ABI/Inform Professional Health Research Premium Collection Natural Science Collection Biological Science Collection ProQuest Medical Library (Alumni) ProQuest Newsstand Professional Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Family Health ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition ProQuest Health Management (Alumni Edition) ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic Calcium & Calcified Tissue Abstracts Pharma and Biotech Premium PRO SIRS Editorial ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Family Health (Alumni Edition) ProQuest Biology Journals (Alumni Edition) ProQuest Central Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Public Health ProQuest Central Basic Toxicology Abstracts ProQuest Science Journals British Nursing Index with Full Text ProQuest Health Management British Nursing Index ProQuest Nursing & Allied Health Source ProQuest Psychology Journals (Alumni) ProQuest SciTech Collection ProQuest Medical Library ProQuest Psychology Journals ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | ProQuest One Psychology |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1474-547X |
| EndPage | 1751 |
| ExternalDocumentID | 2035837701 10_1016_S0140_6736_10_60599_5 20434765 S0140673610605995 1_s2_0_S0140673610605995 |
| Genre | Journal Article Commentary |
| GrantInformation_xml | – fundername: NIGMS NIH HHS grantid: R01 GM079719-04 – fundername: NLM NIH HHS grantid: R01 LM009719 – fundername: NLM NIH HHS grantid: R01 LM009719-02 |
| GroupedDBID | --- --K --M .1- .55 .CO .FO .GJ 04C 0R~ 123 1B1 1P~ 1RT 1~5 29L 3EH 3O- 3V. 4.4 41~ 457 4G. 53G 5VS 7-5 71M 7RV 7X7 88A 88E 88I 8AF 8AO 8C1 8C2 8FE 8FH 8FI 8FJ 8G5 8WZ 9JM A6W AABNK AACTN AAEDT AAEDW AAEJM AAIKJ AAKAS AAKOC AALRI AAMRU AAQFI AAQQT AAQXK AAXKI AAXUO AAYOK ABBQC ABCQX ABDBF ABFNM ABIVO ABJNI ABLJU ABMAC ABMZM ABOCM ABTAH ABUWG ACGFS ACGOD ACIUM ACPRK ACRLP ACRZS ADBBV ADMUD ADZCM AEKER AENEX AEVXI AFCTW AFFNX AFKRA AFKWA AFRAH AFRHN AFTJW AFXIZ AGAPS AGHFR AHHHB AHMBA AITUG AJJEV AJOXV AJRQY AJUYK AKRWK AKVCP ALIPV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AN0 ANZVX AQUVI ARTTT ASPBG AVWKF AXJTR AZFZN AZQEC BBNVY BCU BEC BENPR BHPHI BKEYQ BKNYI BKOJK BKOMP BNPGV BNQBC BPHCQ BVXVI CCPQU CS3 D0S DU5 DWQXO EAP EAS EAU EAZ EBC EBD EBS EBU EFJIC EGS EHN EIHBH EJD EMB EMK EMOBN ENC EO8 EO9 EP2 EP3 EPL EPS EPT ESX EVS EWM EX3 F5P FD8 FDB FEDTE FGOYB FIRID FNPLU FYGXN FYUFA G-2 G-Q GBLVA GNUQQ GUQSH HCIFZ HVGLF HZ~ IHE J1W J5H K-O K9- KOM L7B LK8 LZ2 M0L M0R M0T M1P M2M M2O M2P M41 M7P MJL MO0 MVM N9A NAPCQ O-L O9- OD. OO~ OVD OZT P-8 P-9 P2P PC. PQQKQ PRG PROAC PSQYO PSYQQ Q~Q R2- RIG ROL RPZ S0X SAD SDF SDG SEL SES SJFOW SJN SPCBC SSH SSZ SV3 T5K TEORI TH9 TLN TWZ UAP UBE UHU UQL UV1 WOQ WOW WUQ X7M XAX XDU XPP YYM YYQ Z5R ZGI ZMT ZXP ZY4 ~G0 ABLVK ABYKQ AHPSJ AJBFU HMCUK NHB UKHRP XFK Y6R ZA5 CGR CUY CVF ECM EIF NPM AAYXX ACRPL CITATION 0TT 0TZ 0U~ 7QL 7QP 7TK 7U7 7U9 7XB 8FK ASE C1K FPQ H94 K6X K9. KB~ M7N MBDVC PQEST PQUKI Q9U 7X8 |
| ID | FETCH-LOGICAL-c512t-ed6e9c20314e9ed9f736953cac9369bdb9bb051d4e0e789420c5e936bbe5c9223 |
| IEDL.DBID | 8C1 |
| ISSN | 0140-6736 |
| IngestDate | Wed Dec 04 07:39:24 EST 2024 Tue Nov 19 06:46:49 EST 2024 Fri Dec 06 01:05:20 EST 2024 Sat Sep 28 08:10:51 EDT 2024 Fri Feb 23 02:28:08 EST 2024 Tue Oct 15 22:55:54 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9727 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c512t-ed6e9c20314e9ed9f736953cac9369bdb9bb051d4e0e789420c5e936bbe5c9223 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 20434765 |
| PQID | 288355328 |
| PQPubID | 40246 |
| PageCount | 3 |
| ParticipantIDs | proquest_miscellaneous_733104037 proquest_journals_288355328 crossref_primary_10_1016_S0140_6736_10_60599_5 pubmed_primary_20434765 elsevier_sciencedirect_doi_10_1016_S0140_6736_10_60599_5 elsevier_clinicalkeyesjournals_1_s2_0_S0140673610605995 |
| PublicationCentury | 2000 |
| PublicationDate | 2010-05-15 |
| PublicationDateYYYYMMDD | 2010-05-15 |
| PublicationDate_xml | – month: 05 year: 2010 text: 2010-05-15 day: 15 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: London |
| PublicationTitle | The Lancet (British edition) |
| PublicationTitleAlternate | Lancet |
| PublicationYear | 2010 |
| Publisher | Elsevier Ltd Elsevier Limited |
| Publisher_xml | – name: Elsevier Ltd – name: Elsevier Limited |
| References | Kohane, Masys, Altman (bib3) 2006; 296 Ashley, Butte, Wheeler (bib1) 2010; 375 Peters, Vastfjall, Slovic, Mertz, Mazzocco, Dickert (bib2) 2006; 17 Peters (10.1016/S0140-6736(10)60599-5_bib2) 2006; 17 Kohane (10.1016/S0140-6736(10)60599-5_bib3) 2006; 296 Ashley (10.1016/S0140-6736(10)60599-5_bib1) 2010; 375 |
| References_xml | – volume: 296 start-page: 212 year: 2006 end-page: 215 ident: bib3 article-title: The incidentalome: a threat to genomic medicine publication-title: JAMA contributor: fullname: Altman – volume: 17 start-page: 407 year: 2006 end-page: 413 ident: bib2 article-title: Numeracy and decision making publication-title: Psychol Sci contributor: fullname: Dickert – volume: 375 start-page: 1525 year: 2010 end-page: 1535 ident: bib1 article-title: Clinical assessment incorporating a personal genome publication-title: Lancet contributor: fullname: Wheeler – volume: 375 start-page: 1525 year: 2010 ident: 10.1016/S0140-6736(10)60599-5_bib1 article-title: Clinical assessment incorporating a personal genome publication-title: Lancet doi: 10.1016/S0140-6736(10)60452-7 contributor: fullname: Ashley – volume: 296 start-page: 212 year: 2006 ident: 10.1016/S0140-6736(10)60599-5_bib3 article-title: The incidentalome: a threat to genomic medicine publication-title: JAMA doi: 10.1001/jama.296.2.212 contributor: fullname: Kohane – volume: 17 start-page: 407 year: 2006 ident: 10.1016/S0140-6736(10)60599-5_bib2 article-title: Numeracy and decision making publication-title: Psychol Sci doi: 10.1111/j.1467-9280.2006.01720.x contributor: fullname: Peters |
| SSID | ssj0004605 |
| Score | 2.4766 |
| Snippet | Since whole-genome sequencing will show that every patient has an above-average risk for some disorders, and for having children with some genetic diseases,... |
| SourceID | proquest crossref pubmed elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 1749 |
| SubjectTerms | Family medical history Genes Genetic counseling Genetic Counseling - economics Genetic Predisposition to Disease Genetic Testing - economics Genetics Genome, Human Genome-Wide Association Study - economics Humans Internal Medicine Professional-Patient Relations |
| Title | Challenges in the clinical application of whole-genome sequencing |
| URI | https://www.clinicalkey.es/playcontent/1-s2.0-S0140673610605995 https://dx.doi.org/10.1016/S0140-6736(10)60599-5 https://www.ncbi.nlm.nih.gov/pubmed/20434765 https://www.proquest.com/docview/288355328 https://search.proquest.com/docview/733104037 |
| Volume | 375 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV07T8MwED7RIiEWxJtSqDwwwGDaPJzEE4KqFUICIR5SNyt2XImBtJBW_H3uEicw8FhjXSyf7fsuuccHcJLhuUlFanjmWZ-HMg14YqXlCH3ovgbCM5oiurd30fVzeDMRE5ebU7i0ytomloY6mxn6R94nVlwhAj-5mL9xIo2i4Kpj0GjBqkc4R4XiQ--nssgyw_2rgKf_2Dw89QZnETUp4eI3aPrN9SwhaLwJG853ZJfVZm_Bis23Ye3WRcd34HJYM6MU7CVn6NqxuvCRfQtUs9mUfRAtLqcGra-WuXRqBLFdeB6PnobX3FEkcINIveA2i6w0PvWgRw1ncoorkiIwqSGiPp1pqTVeuyy0AxsnMvQHRlgc0toKI1Fle9DOZ7k9ACakmaZelMipDMM0MIj8QZJSilccal9mHTivtaPmVScM9UOKGD4q1alEB-Jah6peLRomW7hbUihPFb4aVNIkjJ-nJIqSSSPpHIEK4BXa-f8m7da7pZp5mrPTAdaM4jWi2Eia29myUERdifYsiDuwX-1xs0iqHg7jSBz--eourNeJBZ44gvbifWmP0V9Z6B604kncK89mD1avRnf3D584fOWP |
| link.rule.ids | 314,780,784,12056,12223,21388,27924,27925,31719,31720,33266,33267,33744,33745,43310,43579,43805,73745,74014,74302 |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3JTsMwEB1BkYALYqesPnCAg2mzOIlPCCpQWVohKFJvVuy4EgdSIEX8PjONEziwXGNNLI_teZPM8gAOMzw3qUgNzzzr81CmAU-stByhD93XQHhGU0S314-6j-H1UAxdbk7h0iormzg11NnY0D_yFrHiChH4yenLKyfSKAquOgaNWZijxumiAXPnF_27-58KI6c57l8lPK2H-uGR1z6OqE0JF7-B02_O5xSELpdhyXmP7Kzc7hWYsfkqzPdcfHwNzjoVN0rBnnKGzh2rSh_Zt1A1G4_YBxHjcmrR-myZS6hGGFuHx8uLQafLHUkCN4jVE26zyErjUxd61HEmR7giKQKTGqLq05mWWuPFy0LbtnEiQ79thMUhra0wEp2DDWjk49xuARPSjFIvSuRIhmEaGMT-IEkpySsOtS-zJpxU2lEvZS8M9UOSGD6aqlOJJsSVDlW1WjRNtnD3pFCeKnzVLqVJGD9QSRQlk1rSuQIlxCu09P9NulPtlqrnqU9PE1g9iheJoiNpbsfvhSLySrRoQdyEzXKP60VS_XAYR2L7z1cfwEJ30LtVt1f9mx1YrNIMPLELjcnbu91D72Wi990Z_QTWG-ec |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3JTsMwEB1BkSouiJ2y-sABDqbZnMQnBKUVW6uKReJmxY4jcSAtpBW_z7hxAgcK11gTy_Z45iWzPIDjFPUmYYmiqas9GvDEp7HmmqLrQ_jqM1dJE9HtD8Lr5-D2hb3YlkKFTausbOLMUKcjZf6Rtw0rLmO-F7czmxUxvOqdj9-pIZAygVbLprEIS-gUHa8BS5fdwfDhtyLJWb77dzlP-7F-eOI6p6FpWULZPEc1D4jOHFJvFVYskiQX5dGvwYLO16HZt7HyDbjoVDwpBXnNCQI9UpVBkh9hazLKyKchyaWmXeubJja5Gl3aJjz3uk-da2oJE6hCvz2hOg01V57pSI_7nfIMV8SZrxJlaPtkKrmUeAnTQDs6inngOYppHJJSM8URKGxBIx_legcI4ypL3DDmGQ-CxFeIA_w4MQlfUSA9nrbgrNodMS77YohfEsbw0Ww7BWtBVO2hqFaLZkoX9s4UwhWFJ5xS2gjjx6oRRcm4lrSwoHT3Aq3-f5PuVacl6nlqTWoBqUfxUplISZLr0bQQhsgSrZsftWC7PON6kaaWOIhCtvvnq4-gieop7m8Gd3uwXGUcuGwfGpOPqT5AIDORh1ZFvwDi6evJ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Challenges+in+the+clinical+application+of+whole-genome+sequencing&rft.jtitle=The+Lancet+%28British+edition%29&rft.au=Ormond%2C+Kelly+E%2C+MSc&rft.au=Wheeler%2C+Matthew+T%2C+MD&rft.au=Hudgins%2C+Louanne%2C+Prof&rft.au=Klein%2C+Teri+E%2C+PhD&rft.date=2010-05-15&rft.issn=0140-6736&rft.volume=375&rft.issue=9727&rft.spage=1749&rft.epage=1751&rft_id=info:doi/10.1016%2FS0140-6736%2810%2960599-5&rft.externalDBID=ECK1-s2.0-S0140673610605995&rft.externalDocID=1_s2_0_S0140673610605995 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F01406736%2FS0140673610X61268%2Fcov150h.gif |