Sensing intracellular signatures with synthetic mRNAs

The bottom-up assembly of biological components in synthetic biology has contributed to a better understanding of natural phenomena and the development of new technologies for practical applications. Over the past few decades, basic RNA research has unveiled the regulatory roles of RNAs underlying g...

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Bibliographic Details
Published inRNA biology Vol. 20; no. 1; pp. 588 - 602
Main Authors Ono, Hiroki, Saito, Hirohide
Format Journal Article
LanguageEnglish
Published Taylor & Francis 31.12.2023
Taylor & Francis Group
Subjects
miRNA
Review
RNA-binding protein
Synthetic biology
Translational regulation
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Summary:The bottom-up assembly of biological components in synthetic biology has contributed to a better understanding of natural phenomena and the development of new technologies for practical applications. Over the past few decades, basic RNA research has unveiled the regulatory roles of RNAs underlying gene regulatory networks; while advances in RNA biology, in turn, have highlighted the potential of a wide variety of RNA elements as building blocks to construct artificial systems. In particular, synthetic mRNA-based translational regulators, which respond to signals in cells and regulate the production of encoded output proteins, are gaining attention with the recent rise of mRNA therapeutics. In this Review, we discuss recent progress in RNA synthetic biology, mainly focusing on emerging technologies for sensing intracellular protein and RNA molecules and controlling translation.
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ISSN:1547-6286
1555-8584
DOI:10.1080/15476286.2023.2244791