Italian Clinical Practice Guidelines on Cholangiocarcinoma – Part II: Treatment

Currently, the only curative treatment for cholangiocarcinoma (CCA) is surgical resection, though this treatment is possible in less than 40% of patients. However, recent improvements in preoperative management have led to a higher number of patients who are candidates for this procedure. For unrese...

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Published inDigestive and liver disease Vol. 52; no. 12; pp. 1430 - 1442
Main Authors Alvaro, Domenico, Hassan, Cesare, Cardinale, Vincenzo, Carpino, Guido, Fabris, Luca, Gringeri, Enrico, Granata, Vincenza, Mutignani, Massimiliano, Morement, Helen, Giuliante, Felice, Guglielmi, Alfredo, Ridola, Lorenzo, Tonini, Giuseppe, Marzioni, Marco, Grazi, Gianluca, Guido, Maria, Di Giulio, Emilio, Pantano, Francesco, Venere, Rosanna, Bragazzi, Maria Consiglia, Biancanello, Francesca, Faccioli, Jessica, Giannetti, Aurora, Cintolo, Marcello, Di Giunta, Michela, Gambato, Martina, Lasagni, Alberto, Izzo, Francesco, Avallone, Antonio, Banales, Jesus, Rossi, Massimo, Catalano, Carlo, Laghi, Andrea, D'amati, Giulia, Mancino, Maria Grazia
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.12.2020
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Abstract Currently, the only curative treatment for cholangiocarcinoma (CCA) is surgical resection, though this treatment is possible in less than 40% of patients. However, recent improvements in preoperative management have led to a higher number of patients who are candidates for this procedure. For unresectable patients, progress is ongoing in terms of locoregional and chemoradiation treatments and target therapies, especially in the definition of patient selection criteria. This is the second part of the Italian CCA guidelines, dealing with CCA treatment, that have been formulated in accordance with Italian National Institute of Health indications and developed according to the GRADE method and related advancements.
AbstractList Currently, the only curative treatment for cholangiocarcinoma (CCA) is surgical resection, though this treatment is possible in less than 40% of patients. However, recent improvements in preoperative management have led to a higher number of patients who are candidates for this procedure. For unresectable patients, progress is ongoing in terms of locoregional and chemoradiation treatments and target therapies, especially in the definition of patient selection criteria. This is the second part of the Italian CCA guidelines, dealing with CCA treatment, that have been formulated in accordance with Italian National Institute of Health indications and developed according to the GRADE method and related advancements.Currently, the only curative treatment for cholangiocarcinoma (CCA) is surgical resection, though this treatment is possible in less than 40% of patients. However, recent improvements in preoperative management have led to a higher number of patients who are candidates for this procedure. For unresectable patients, progress is ongoing in terms of locoregional and chemoradiation treatments and target therapies, especially in the definition of patient selection criteria. This is the second part of the Italian CCA guidelines, dealing with CCA treatment, that have been formulated in accordance with Italian National Institute of Health indications and developed according to the GRADE method and related advancements.
Currently, the only curative treatment for cholangiocarcinoma (CCA) is surgical resection, though this treatment is possible in less than 40% of patients. However, recent improvements in preoperative management have led to a higher number of patients who are candidates for this procedure. For unresectable patients, progress is ongoing in terms of locoregional and chemoradiation treatments and target therapies, especially in the definition of patient selection criteria. This is the second part of the Italian CCA guidelines, dealing with CCA treatment, that have been formulated in accordance with Italian National Institute of Health indications and developed according to the GRADE method and related advancements.
Author Gringeri, Enrico
Alvaro, Domenico
Izzo, Francesco
Morement, Helen
Ridola, Lorenzo
Fabris, Luca
Gambato, Martina
Granata, Vincenza
Rossi, Massimo
Catalano, Carlo
Cardinale, Vincenzo
Giuliante, Felice
Carpino, Guido
Faccioli, Jessica
Avallone, Antonio
Laghi, Andrea
Di Giulio, Emilio
Grazi, Gianluca
Mutignani, Massimiliano
Guglielmi, Alfredo
Tonini, Giuseppe
Guido, Maria
Cintolo, Marcello
Biancanello, Francesca
D'amati, Giulia
Pantano, Francesco
Marzioni, Marco
Bragazzi, Maria Consiglia
Venere, Rosanna
Banales, Jesus
Mancino, Maria Grazia
Hassan, Cesare
Di Giunta, Michela
Giannetti, Aurora
Lasagni, Alberto
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  surname: Catalano
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/32952071$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Contributor Gringeri, Enrico
Alvaro, Domenico
Izzo, Francesco
Morement, Helen
Ridola, Lorenzo
Fabris, Luca
Gambato, Martina
Granata, Vincenza
Rossi, Massimo
Catalano, Carlo
Cardinale, Vincenzo
Giuliante, Felice
Carpino, Guido
Faccioli, Jessica
Avallone, Antonio
Laghi, Andrea
Di Giulio, Emilio
Grazi, Gianluca
Mutignani, Massimiliano
Guglielmi, Alfredo
Tonini, Giuseppe
Guido, Maria
Cintolo, Marcello
Biancanello, Francesca
D'amati, Giulia
Pantano, Francesco
Marzioni, Marco
Bragazzi, Maria Consiglia
Venere, Rosanna
Banales, Jesus
Mancino, Maria Grazia
Hassan, Cesare
Di Giunta, Michela
Giannetti, Aurora
Lasagni, Alberto
Contributor_xml – sequence: 1
  givenname: Domenico
  surname: Alvaro
  fullname: Alvaro, Domenico
  email: domenico.alvaro@uniroma1.it
  organization: Chair, AISF and SIGE, Department of Translational and Precision Medicine, "Sapienza" University of Rome, Italy. Electronic address: domenico.alvaro@uniroma1.it
– sequence: 2
  givenname: Cesare
  surname: Hassan
  fullname: Hassan, Cesare
  organization: Co-Chair, Gastroenterology Unit, Nuovo Regina Margherita Hospital, Rome, Italy
– sequence: 3
  givenname: Vincenzo
  surname: Cardinale
  fullname: Cardinale, Vincenzo
  organization: AISF, SIGE; Department of Medical- Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy
– sequence: 4
  givenname: Guido
  surname: Carpino
  fullname: Carpino, Guido
  organization: AISF; Department of Movement, Human and Health Sciences, Division of Health Sciences, University of Rome "Foro Italico", Rome, Italy
– sequence: 5
  givenname: Luca
  surname: Fabris
  fullname: Fabris, Luca
  organization: AISF, SIGE; Department of Molecular Medicine, Azienda Ospedaliera/Universitàdi Padova, Padova, Italy
– sequence: 6
  givenname: Enrico
  surname: Gringeri
  fullname: Gringeri, Enrico
  organization: SITO; Hepatobiliary Surgery and Liver Transplantation Unit, Department of Surgery Oncology and Gas- troenterology, DISCOG, Padova, Italy
– sequence: 7
  givenname: Vincenza
  surname: Granata
  fullname: Granata, Vincenza
  organization: SIRM; Division of Radiology, Istituto Nazionale dei Tumori, IRCCS, Fondazione Pascale, Napoli, Italy
– sequence: 8
  givenname: Massimiliano
  surname: Mutignani
  fullname: Mutignani, Massimiliano
  organization: SIGE; Digestive Endoscopy Unit, ASST Niguarda, Milan, Italy
– sequence: 9
  givenname: Helen
  surname: Morement
  fullname: Morement, Helen
  organization: AMMF - The Cholangiocarcinoma Charity, United Kingdom
– sequence: 10
  givenname: Felice
  surname: Giuliante
  fullname: Giuliante, Felice
  organization: SIC; Unit of Hepatobiliary Surgery, Fon- dazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy
– sequence: 11
  givenname: Alfredo
  surname: Guglielmi
  fullname: Guglielmi, Alfredo
  organization: IT-IHPBA; Department of Surgery, Division of General and Hepatobiliary Surgery, G.B. Rossi University Hospital, University of Verona, Verona, Italy
– sequence: 12
  givenname: Lorenzo
  surname: Ridola
  fullname: Ridola, Lorenzo
  organization: AISF, SIGE; Department of Translational and Precision Medicine, "Sapienza" University of Rome, Italy
– sequence: 13
  givenname: Giuseppe
  surname: Tonini
  fullname: Tonini, Giuseppe
  organization: Department of Medical Oncology, University Campus Bio-Medico, Rome, Italy
– sequence: 14
  givenname: Marco
  surname: Marzioni
  fullname: Marzioni, Marco
  organization: Department of Gastroenterology and Hepatology, Università Politecnica delle Marche, Ancona, Italy
– sequence: 15
  givenname: Gianluca
  surname: Grazi
  fullname: Grazi, Gianluca
  organization: Division of Hepatopancreatobiliary Surgery, Department of Surgery, IRCCS-Regina Elena National Cancer Institute, Rome, Italy
– sequence: 16
  givenname: Maria
  surname: Guido
  fullname: Guido, Maria
  organization: Department of Medicine-DIMED, University of Padova, Italy
– sequence: 17
  givenname: Emilio
  surname: Di Giulio
  fullname: Di Giulio, Emilio
  organization: Department of Medical-Surgical Sciences and Translational Medicine, "Sapienza" University of Rome, Rome, Italy
– sequence: 18
  givenname: Francesco
  surname: Pantano
  fullname: Pantano, Francesco
  organization: Department of Medical Oncology, University Campus Bio-Medico, Rome, Italy
– sequence: 19
  givenname: Rosanna
  surname: Venere
  fullname: Venere, Rosanna
  organization: Department of Translational and Precision Medicine, "Sapienza" University of Rome, Italy
– sequence: 20
  givenname: Maria Consiglia
  surname: Bragazzi
  fullname: Bragazzi, Maria Consiglia
  organization: Gastroenterology Unit, Santa Maria Goretti Hospital, Latina, Italy
– sequence: 21
  givenname: Francesca
  surname: Biancanello
  fullname: Biancanello, Francesca
  organization: Department of Medical-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy
– sequence: 22
  givenname: Jessica
  surname: Faccioli
  fullname: Faccioli, Jessica
  organization: Department of Translational and Precision Medicine, "Sapienza" University of Rome, Italy
– sequence: 23
  givenname: Aurora
  surname: Giannetti
  fullname: Giannetti, Aurora
  organization: Digestive Endoscopy Unit, ASST Niguarda, Milan, Italy
– sequence: 24
  givenname: Marcello
  surname: Cintolo
  fullname: Cintolo, Marcello
  organization: Digestive Endoscopy Unit, ASST Niguarda, Milan, Italy
– sequence: 25
  givenname: Michela
  surname: Di Giunta
  fullname: Di Giunta, Michela
  organization: Hepatobiliary Surgery and Liver Transplantation Unit, Department of Surgery Oncology and Gastroenterology, DISCOG, Padova, Italy
– sequence: 26
  givenname: Martina
  surname: Gambato
  fullname: Gambato, Martina
  organization: Multivisceral Transplant Unit and Gastroenterology, Department of Surgery Oncology and Gastroenterology, DISCOG, Padova, Italy
– sequence: 27
  givenname: Alberto
  surname: Lasagni
  fullname: Lasagni, Alberto
  organization: Department of Molecular Medicine, Azienda Ospedaliera/Universitàdi Padova, Italy
– sequence: 28
  givenname: Francesco
  surname: Izzo
  fullname: Izzo, Francesco
  organization: Division of Hepatobiliary Surgery, Istituto Nazionale dei Tumori, IRCCS, Fondazione Pascale, Naples, Italy
– sequence: 29
  givenname: Antonio
  surname: Avallone
  fullname: Avallone, Antonio
  organization: Division of Abdominal Oncology, Istituto Nazionale dei Tumori, IRCCS, Fondazione Pascale, Naples, Italy
– sequence: 30
  givenname: Jesus
  surname: Banales
  fullname: Banales, Jesus
  organization: Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute - Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain
– sequence: 31
  givenname: Massimo
  surname: Rossi
  fullname: Rossi, Massimo
  organization: Hepato-bilio-pancreatic and Liver Transplant Unit, Department of Surgery, "Sapienza" University of Rome, Italy
– sequence: 32
  givenname: Carlo
  surname: Catalano
  fullname: Catalano, Carlo
  organization: Department of Radiological, Oncological and Anatomopathological Sciences, "Sapienza" University of Rome, Rome, Italy
– sequence: 33
  givenname: Andrea
  surname: Laghi
  fullname: Laghi, Andrea
  organization: Department of Medical-Surgical Sciences and Translational Medicine, "Sapienza" University of Rome, Rome, Italy
– sequence: 34
  givenname: Giulia
  surname: D'amati
  fullname: D'amati, Giulia
  organization: Department of Radiological, Oncological and Pathological Sciences, "Sapienza" University of Rome, Rome, Italy
– sequence: 35
  givenname: Maria Grazia
  surname: Mancino
  fullname: Mancino, Maria Grazia
  organization: UOC Gastroenterologia ed Endoscopia Digestiva AORN Sant'Anna e San Sebastiano, Caserta, Italy
– sequence: 36
  givenname: Lorenzo
  surname: Ridola
  fullname: Ridola, Lorenzo
  organization: Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy
Copyright 2020 Editrice Gastroenterologica Italiana S.r.l.
Copyright © 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
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Issue 12
Keywords Surgery
Intrahepatic cholangiocarcinoma
Locoregional treatments
Perihilar cholangiocarcinoma
Distal cholangiocarcinoma
Target therapies
Liver transplantation
Language English
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Snippet Currently, the only curative treatment for cholangiocarcinoma (CCA) is surgical resection, though this treatment is possible in less than 40% of patients....
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SubjectTerms Distal cholangiocarcinoma
Intrahepatic cholangiocarcinoma
Liver transplantation
Locoregional treatments
Perihilar cholangiocarcinoma
Surgery
Target therapies
Title Italian Clinical Practice Guidelines on Cholangiocarcinoma – Part II: Treatment
URI https://www.clinicalkey.com/#!/content/1-s2.0-S1590865820304497
https://dx.doi.org/10.1016/j.dld.2020.08.030
https://www.ncbi.nlm.nih.gov/pubmed/32952071
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