Italian Clinical Practice Guidelines on Cholangiocarcinoma – Part II: Treatment
Currently, the only curative treatment for cholangiocarcinoma (CCA) is surgical resection, though this treatment is possible in less than 40% of patients. However, recent improvements in preoperative management have led to a higher number of patients who are candidates for this procedure. For unrese...
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Published in | Digestive and liver disease Vol. 52; no. 12; pp. 1430 - 1442 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Ltd
01.12.2020
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Subjects | |
Online Access | Get full text |
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Abstract | Currently, the only curative treatment for cholangiocarcinoma (CCA) is surgical resection, though this treatment is possible in less than 40% of patients. However, recent improvements in preoperative management have led to a higher number of patients who are candidates for this procedure. For unresectable patients, progress is ongoing in terms of locoregional and chemoradiation treatments and target therapies, especially in the definition of patient selection criteria. This is the second part of the Italian CCA guidelines, dealing with CCA treatment, that have been formulated in accordance with Italian National Institute of Health indications and developed according to the GRADE method and related advancements. |
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AbstractList | Currently, the only curative treatment for cholangiocarcinoma (CCA) is surgical resection, though this treatment is possible in less than 40% of patients. However, recent improvements in preoperative management have led to a higher number of patients who are candidates for this procedure. For unresectable patients, progress is ongoing in terms of locoregional and chemoradiation treatments and target therapies, especially in the definition of patient selection criteria. This is the second part of the Italian CCA guidelines, dealing with CCA treatment, that have been formulated in accordance with Italian National Institute of Health indications and developed according to the GRADE method and related advancements.Currently, the only curative treatment for cholangiocarcinoma (CCA) is surgical resection, though this treatment is possible in less than 40% of patients. However, recent improvements in preoperative management have led to a higher number of patients who are candidates for this procedure. For unresectable patients, progress is ongoing in terms of locoregional and chemoradiation treatments and target therapies, especially in the definition of patient selection criteria. This is the second part of the Italian CCA guidelines, dealing with CCA treatment, that have been formulated in accordance with Italian National Institute of Health indications and developed according to the GRADE method and related advancements. Currently, the only curative treatment for cholangiocarcinoma (CCA) is surgical resection, though this treatment is possible in less than 40% of patients. However, recent improvements in preoperative management have led to a higher number of patients who are candidates for this procedure. For unresectable patients, progress is ongoing in terms of locoregional and chemoradiation treatments and target therapies, especially in the definition of patient selection criteria. This is the second part of the Italian CCA guidelines, dealing with CCA treatment, that have been formulated in accordance with Italian National Institute of Health indications and developed according to the GRADE method and related advancements. |
Author | Gringeri, Enrico Alvaro, Domenico Izzo, Francesco Morement, Helen Ridola, Lorenzo Fabris, Luca Gambato, Martina Granata, Vincenza Rossi, Massimo Catalano, Carlo Cardinale, Vincenzo Giuliante, Felice Carpino, Guido Faccioli, Jessica Avallone, Antonio Laghi, Andrea Di Giulio, Emilio Grazi, Gianluca Mutignani, Massimiliano Guglielmi, Alfredo Tonini, Giuseppe Guido, Maria Cintolo, Marcello Biancanello, Francesca D'amati, Giulia Pantano, Francesco Marzioni, Marco Bragazzi, Maria Consiglia Venere, Rosanna Banales, Jesus Mancino, Maria Grazia Hassan, Cesare Di Giunta, Michela Giannetti, Aurora Lasagni, Alberto |
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Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy – sequence: 11 givenname: Alfredo surname: Guglielmi fullname: Guglielmi, Alfredo organization: IT-IHPBA; Department of Surgery, Division of General and Hepatobiliary Surgery, G.B. Rossi University Hospital, University of Verona, Verona, Italy – sequence: 12 givenname: Lorenzo surname: Ridola fullname: Ridola, Lorenzo organization: AISF, SIGE; Department of Translational and Precision Medicine, "Sapienza" University of Rome, Italy – sequence: 13 givenname: Giuseppe surname: Tonini fullname: Tonini, Giuseppe organization: Department of Medical Oncology, University Campus Bio-Medico, Rome, Italy – sequence: 14 givenname: Marco surname: Marzioni fullname: Marzioni, Marco organization: Department of Gastroenterology and Hepatology, Università Politecnica delle Marche, Ancona, Italy – sequence: 15 givenname: Gianluca surname: Grazi fullname: Grazi, Gianluca organization: Division of Hepatopancreatobiliary Surgery, Department of Surgery, IRCCS-Regina Elena National Cancer Institute, Rome, Italy – sequence: 16 givenname: Maria surname: Guido fullname: Guido, Maria organization: Department of Medicine-DIMED, University of Padova, Italy – sequence: 17 givenname: Emilio surname: Di Giulio fullname: Di Giulio, Emilio organization: Department of Medical-Surgical Sciences and Translational Medicine, "Sapienza" University of Rome, Rome, Italy – sequence: 18 givenname: Francesco surname: Pantano fullname: Pantano, Francesco organization: Department of Medical Oncology, University Campus Bio-Medico, Rome, Italy – sequence: 19 givenname: Rosanna surname: Venere fullname: Venere, Rosanna organization: Department of Translational and Precision Medicine, "Sapienza" University of Rome, Italy – sequence: 20 givenname: Maria Consiglia surname: Bragazzi fullname: Bragazzi, Maria Consiglia organization: Gastroenterology Unit, Santa Maria Goretti Hospital, Latina, Italy – sequence: 21 givenname: Francesca surname: Biancanello fullname: Biancanello, Francesca organization: Department of Medical-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy – sequence: 22 givenname: Jessica surname: Faccioli fullname: Faccioli, Jessica organization: Department of Translational and Precision Medicine, "Sapienza" University of Rome, Italy – sequence: 23 givenname: Aurora surname: Giannetti fullname: Giannetti, Aurora organization: Digestive Endoscopy Unit, ASST Niguarda, Milan, Italy – sequence: 24 givenname: Marcello surname: Cintolo fullname: Cintolo, Marcello organization: Digestive Endoscopy Unit, ASST Niguarda, Milan, Italy – sequence: 25 givenname: Michela surname: Di Giunta fullname: Di Giunta, Michela organization: Hepatobiliary Surgery and Liver Transplantation Unit, Department of Surgery Oncology and Gastroenterology, DISCOG, Padova, Italy – sequence: 26 givenname: Martina surname: Gambato fullname: Gambato, Martina organization: Multivisceral Transplant Unit and Gastroenterology, Department of Surgery Oncology and Gastroenterology, DISCOG, Padova, Italy – sequence: 27 givenname: Alberto surname: Lasagni fullname: Lasagni, Alberto organization: Department of Molecular Medicine, Azienda Ospedaliera/Universitàdi Padova, Italy – sequence: 28 givenname: Francesco surname: Izzo fullname: Izzo, Francesco organization: Division of Hepatobiliary Surgery, Istituto Nazionale dei Tumori, IRCCS, Fondazione Pascale, Naples, Italy – sequence: 29 givenname: Antonio surname: Avallone fullname: Avallone, Antonio organization: Division of Abdominal Oncology, Istituto Nazionale dei Tumori, IRCCS, Fondazione Pascale, Naples, Italy – sequence: 30 givenname: Jesus surname: Banales fullname: Banales, Jesus organization: Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute - Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain – sequence: 31 givenname: Massimo surname: Rossi fullname: Rossi, Massimo organization: Hepato-bilio-pancreatic and Liver Transplant Unit, Department of Surgery, "Sapienza" University of Rome, Italy – sequence: 32 givenname: Carlo surname: Catalano fullname: Catalano, Carlo organization: Department of Radiological, Oncological and Anatomopathological Sciences, "Sapienza" University of Rome, Rome, Italy – sequence: 33 givenname: Andrea surname: Laghi fullname: Laghi, Andrea organization: Department of Medical-Surgical Sciences and Translational Medicine, "Sapienza" University of Rome, Rome, Italy – sequence: 34 givenname: Giulia surname: D'amati fullname: D'amati, Giulia organization: Department of Radiological, Oncological and Pathological Sciences, "Sapienza" University of Rome, Rome, Italy – sequence: 35 givenname: Maria Grazia surname: Mancino fullname: Mancino, Maria Grazia organization: UOC Gastroenterologia ed Endoscopia Digestiva AORN Sant'Anna e San Sebastiano, Caserta, Italy – sequence: 36 givenname: Lorenzo surname: Ridola fullname: Ridola, Lorenzo organization: Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32952071$$D View this record in MEDLINE/PubMed |
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ContentType | Journal Article |
Contributor | Gringeri, Enrico Alvaro, Domenico Izzo, Francesco Morement, Helen Ridola, Lorenzo Fabris, Luca Gambato, Martina Granata, Vincenza Rossi, Massimo Catalano, Carlo Cardinale, Vincenzo Giuliante, Felice Carpino, Guido Faccioli, Jessica Avallone, Antonio Laghi, Andrea Di Giulio, Emilio Grazi, Gianluca Mutignani, Massimiliano Guglielmi, Alfredo Tonini, Giuseppe Guido, Maria Cintolo, Marcello Biancanello, Francesca D'amati, Giulia Pantano, Francesco Marzioni, Marco Bragazzi, Maria Consiglia Venere, Rosanna Banales, Jesus Mancino, Maria Grazia Hassan, Cesare Di Giunta, Michela Giannetti, Aurora Lasagni, Alberto |
Contributor_xml | – sequence: 1 givenname: Domenico surname: Alvaro fullname: Alvaro, Domenico email: domenico.alvaro@uniroma1.it organization: Chair, AISF and SIGE, Department of Translational and Precision Medicine, "Sapienza" University of Rome, Italy. Electronic address: domenico.alvaro@uniroma1.it – sequence: 2 givenname: Cesare surname: Hassan fullname: Hassan, Cesare organization: Co-Chair, Gastroenterology Unit, Nuovo Regina Margherita Hospital, Rome, Italy – sequence: 3 givenname: Vincenzo surname: Cardinale fullname: Cardinale, Vincenzo organization: AISF, SIGE; Department of Medical- Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy – sequence: 4 givenname: Guido surname: Carpino fullname: Carpino, Guido organization: AISF; Department of Movement, Human and Health Sciences, Division of Health Sciences, University of Rome "Foro Italico", Rome, Italy – sequence: 5 givenname: Luca surname: Fabris fullname: Fabris, Luca organization: AISF, SIGE; Department of Molecular Medicine, Azienda Ospedaliera/Universitàdi Padova, Padova, Italy – sequence: 6 givenname: Enrico surname: Gringeri fullname: Gringeri, Enrico organization: SITO; Hepatobiliary Surgery and Liver Transplantation Unit, Department of Surgery Oncology and Gas- troenterology, DISCOG, Padova, Italy – sequence: 7 givenname: Vincenza surname: Granata fullname: Granata, Vincenza organization: SIRM; Division of Radiology, Istituto Nazionale dei Tumori, IRCCS, Fondazione Pascale, Napoli, Italy – sequence: 8 givenname: Massimiliano surname: Mutignani fullname: Mutignani, Massimiliano organization: SIGE; Digestive Endoscopy Unit, ASST Niguarda, Milan, Italy – sequence: 9 givenname: Helen surname: Morement fullname: Morement, Helen organization: AMMF - The Cholangiocarcinoma Charity, United Kingdom – sequence: 10 givenname: Felice surname: Giuliante fullname: Giuliante, Felice organization: SIC; Unit of Hepatobiliary Surgery, Fon- dazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy – sequence: 11 givenname: Alfredo surname: Guglielmi fullname: Guglielmi, Alfredo organization: IT-IHPBA; Department of Surgery, Division of General and Hepatobiliary Surgery, G.B. Rossi University Hospital, University of Verona, Verona, Italy – sequence: 12 givenname: Lorenzo surname: Ridola fullname: Ridola, Lorenzo organization: AISF, SIGE; Department of Translational and Precision Medicine, "Sapienza" University of Rome, Italy – sequence: 13 givenname: Giuseppe surname: Tonini fullname: Tonini, Giuseppe organization: Department of Medical Oncology, University Campus Bio-Medico, Rome, Italy – sequence: 14 givenname: Marco surname: Marzioni fullname: Marzioni, Marco organization: Department of Gastroenterology and Hepatology, Università Politecnica delle Marche, Ancona, Italy – sequence: 15 givenname: Gianluca surname: Grazi fullname: Grazi, Gianluca organization: Division of Hepatopancreatobiliary Surgery, Department of Surgery, IRCCS-Regina Elena National Cancer Institute, Rome, Italy – sequence: 16 givenname: Maria surname: Guido fullname: Guido, Maria organization: Department of Medicine-DIMED, University of Padova, Italy – sequence: 17 givenname: Emilio surname: Di Giulio fullname: Di Giulio, Emilio organization: Department of Medical-Surgical Sciences and Translational Medicine, "Sapienza" University of Rome, Rome, Italy – sequence: 18 givenname: Francesco surname: Pantano fullname: Pantano, Francesco organization: Department of Medical Oncology, University Campus Bio-Medico, Rome, Italy – sequence: 19 givenname: Rosanna surname: Venere fullname: Venere, Rosanna organization: Department of Translational and Precision Medicine, "Sapienza" University of Rome, Italy – sequence: 20 givenname: Maria Consiglia surname: Bragazzi fullname: Bragazzi, Maria Consiglia organization: Gastroenterology Unit, Santa Maria Goretti Hospital, Latina, Italy – sequence: 21 givenname: Francesca surname: Biancanello fullname: Biancanello, Francesca organization: Department of Medical-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy – sequence: 22 givenname: Jessica surname: Faccioli fullname: Faccioli, Jessica organization: Department of Translational and Precision Medicine, "Sapienza" University of Rome, Italy – sequence: 23 givenname: Aurora surname: Giannetti fullname: Giannetti, Aurora organization: Digestive Endoscopy Unit, ASST Niguarda, Milan, Italy – sequence: 24 givenname: Marcello surname: Cintolo fullname: Cintolo, Marcello organization: Digestive Endoscopy Unit, ASST Niguarda, Milan, Italy – sequence: 25 givenname: Michela surname: Di Giunta fullname: Di Giunta, Michela organization: Hepatobiliary Surgery and Liver Transplantation Unit, Department of Surgery Oncology and Gastroenterology, DISCOG, Padova, Italy – sequence: 26 givenname: Martina surname: Gambato fullname: Gambato, Martina organization: Multivisceral Transplant Unit and Gastroenterology, Department of Surgery Oncology and Gastroenterology, DISCOG, Padova, Italy – sequence: 27 givenname: Alberto surname: Lasagni fullname: Lasagni, Alberto organization: Department of Molecular Medicine, Azienda Ospedaliera/Universitàdi Padova, Italy – sequence: 28 givenname: Francesco surname: Izzo fullname: Izzo, Francesco organization: Division of Hepatobiliary Surgery, Istituto Nazionale dei Tumori, IRCCS, Fondazione Pascale, Naples, Italy – sequence: 29 givenname: Antonio surname: Avallone fullname: Avallone, Antonio organization: Division of Abdominal Oncology, Istituto Nazionale dei Tumori, IRCCS, Fondazione Pascale, Naples, Italy – sequence: 30 givenname: Jesus surname: Banales fullname: Banales, Jesus organization: Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute - Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain – sequence: 31 givenname: Massimo surname: Rossi fullname: Rossi, Massimo organization: Hepato-bilio-pancreatic and Liver Transplant Unit, Department of Surgery, "Sapienza" University of Rome, Italy – sequence: 32 givenname: Carlo surname: Catalano fullname: Catalano, Carlo organization: Department of Radiological, Oncological and Anatomopathological Sciences, "Sapienza" University of Rome, Rome, Italy – sequence: 33 givenname: Andrea surname: Laghi fullname: Laghi, Andrea organization: Department of Medical-Surgical Sciences and Translational Medicine, "Sapienza" University of Rome, Rome, Italy – sequence: 34 givenname: Giulia surname: D'amati fullname: D'amati, Giulia organization: Department of Radiological, Oncological and Pathological Sciences, "Sapienza" University of Rome, Rome, Italy – sequence: 35 givenname: Maria Grazia surname: Mancino fullname: Mancino, Maria Grazia organization: UOC Gastroenterologia ed Endoscopia Digestiva AORN Sant'Anna e San Sebastiano, Caserta, Italy – sequence: 36 givenname: Lorenzo surname: Ridola fullname: Ridola, Lorenzo organization: Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy |
Copyright | 2020 Editrice Gastroenterologica Italiana S.r.l. Copyright © 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. |
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Keywords | Surgery Intrahepatic cholangiocarcinoma Locoregional treatments Perihilar cholangiocarcinoma Distal cholangiocarcinoma Target therapies Liver transplantation |
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SubjectTerms | Distal cholangiocarcinoma Intrahepatic cholangiocarcinoma Liver transplantation Locoregional treatments Perihilar cholangiocarcinoma Surgery Target therapies |
Title | Italian Clinical Practice Guidelines on Cholangiocarcinoma – Part II: Treatment |
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