Hydrogen sulfide prodrugs—a review

Hydrogen sul fi de（H2S） is recognized as one of three gasotransmitters together with nitric oxide（NO） and carbon monoxide（CO）. As a signaling molecule, H2S plays an important role in physiology and shows great potential in pharmaceutical applications. Along this line, there is a need for the develop...

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Published inActa pharmaceutica Sinica. B Vol. 5; no. 5; pp. 367 - 377
Main Authors Zheng, Yueqin, Ji, Xingyue, Ji, Kaili, Wang, Binghe
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier 01.09.2015
Subjects
Controllable H2S prodrugs
Gasotransmitters
H2S prodrugs
H2S-hybrid nonsteroidal anti-inflammatory drugs
Hydrogen sulfide (H2S)
Hydrolysis-based H2S prodrugs
Review
H2S-hybrid nonsteroidal anti-inflammatory drugs
Hydrogen sulfide (H2S)
Controllable H2S prodrugs
H2S prodrugs
Hydrolysis-based H2S prodrugs
Gasotransmitters
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Summary:Hydrogen sul fi de（H2S） is recognized as one of three gasotransmitters together with nitric oxide（NO） and carbon monoxide（CO）. As a signaling molecule, H2S plays an important role in physiology and shows great potential in pharmaceutical applications. Along this line, there is a need for the development of H2S prodrugs for various reasons. In this review, we summarize different H2S prodrugs, their chemical properties, and some of their potential therapeutic applications.
Bibliography:10-1171/R
Yueqin Zheng;Xingyue Ji;Kaili Ji;Binghe Wang;Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2211-3835
2211-3843
DOI:10.1016/j.apsb.2015.06.004