Telomerase as a “stemness” enzyme

Pluripotent or multipotent stem cells are involved in development and tissue homeostasis;they have the ability to self-renew and differentiate into various types of functional cells. To maintain these properties,stem cells must undergo sustained or unlimited proliferation that requires the stabiliza...

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Bibliographic Details
Published inScience China. Life sciences Vol. 57; no. 6; pp. 564 - 570
Main Authors Kong, Feng, Zheng, ChengYun, Xu, DaWei
Format Journal Article
LanguageEnglish
Published Beijing Science China Press 01.06.2014
Springer Nature B.V
Subjects
Animals
Biomedical and Life Sciences
DNA聚合酶
Gene Expression
Humans
Induced Pluripotent Stem Cells - enzymology
Life Sciences
Neoplasms - enzymology
Neoplasms - genetics
Neoplastic Stem Cells - enzymology
Protein Subunits
Review
Stem Cells - enzymology
Telomerase - chemistry
Telomerase - genetics
Telomerase - physiology
Telomere Homeostasis - genetics
Telomere Homeostasis - physiology
寿命延长
干性
干细胞
端粒DNA
端粒酶
细胞表型
自我更新
stem cells
telomerase
telomere
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Summary:Pluripotent or multipotent stem cells are involved in development and tissue homeostasis;they have the ability to self-renew and differentiate into various types of functional cells. To maintain these properties,stem cells must undergo sustained or unlimited proliferation that requires the stabilization of telomeres,which are essential for chromosome end protection. Telomerase,an RNA-dependent DNA polymerase,synthesizes telomeric DNA. Through the lengthening of telomeres the lifespans of cells are extended,or indefinite proliferation is conferred;this is intimately associated with stem cell phenotype. This review highlights our current understanding of telomerase as a ＂stemness＂ enzyme and discusses the underlying implications.
Bibliography:11-5841/Q
stem cells;telomerase;telomere;genomic stability;iPS cells;TERC;TERT
Pluripotent or multipotent stem cells are involved in development and tissue homeostasis;they have the ability to self-renew and differentiate into various types of functional cells. To maintain these properties,stem cells must undergo sustained or unlimited proliferation that requires the stabilization of telomeres,which are essential for chromosome end protection. Telomerase,an RNA-dependent DNA polymerase,synthesizes telomeric DNA. Through the lengthening of telomeres the lifespans of cells are extended,or indefinite proliferation is conferred;this is intimately associated with stem cell phenotype. This review highlights our current understanding of telomerase as a ＂stemness＂ enzyme and discusses the underlying implications.
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ISSN:1674-7305
1869-1889
1869-1889
DOI:10.1007/s11427-014-4666-6