Colon-Targeted Oral Drug Delivery Systems: Design Trends and Approaches

• Published in: AAPS PharmSciTech Vol. 16; no. 4; pp. 731 - 741
• Main Authors: Amidon, Seth, Brown, Jack E., Dave, Vivek S.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2015
• Subjects: Administration, Oral; Biochemistry; Biological Availability; Biomedical and Life Sciences; Biomedicine; Biotechnology; Colon - drug effects; Drug Delivery Systems; Humans; Intestinal Absorption; Pharmacology/Toxicology; Pharmacy; Review; Review Article; factors affecting colon delivery; colon targeting; novel approaches; traditional approaches; future trends

Colon-specific drug delivery systems (CDDS) are desirable for the treatment of a range of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. In addition, the colon can be a potential site for the systemic absorption of seve...