Colon-Targeted Oral Drug Delivery Systems: Design Trends and Approaches

Colon-specific drug delivery systems (CDDS) are desirable for the treatment of a range of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. In addition, the colon can be a potential site for the systemic absorption of seve...

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Bibliographic Details
Published inAAPS PharmSciTech Vol. 16; no. 4; pp. 731 - 741
Main Authors Amidon, Seth, Brown, Jack E., Dave, Vivek S.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2015
Subjects
Administration, Oral
Biochemistry
Biological Availability
Biomedical and Life Sciences
Biomedicine
Biotechnology
Colon - drug effects
Drug Delivery Systems
Humans
Intestinal Absorption
Pharmacology/Toxicology
Pharmacy
Review
Review Article
factors affecting colon delivery
colon targeting
novel approaches
traditional approaches
future trends
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Summary:Colon-specific drug delivery systems (CDDS) are desirable for the treatment of a range of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. In addition, the colon can be a potential site for the systemic absorption of several drugs to treat non-colonic conditions. Drugs such as proteins and peptides that are known to degrade in the extreme gastric pH, if delivered to the colon intact, can be systemically absorbed by colonic mucosa. In order to achieve effective therapeutic outcomes, it is imperative that the designed delivery system specifically targets the drugs into the colon. Several formulation approaches have been explored in the development colon-targeted drug delivery systems. These approaches involve the use of formulation components that interact with one or more aspects of gastrointestinal (GI) physiology, such as the difference in the pH along the GI tract, the presence of colonic microflora, and enzymes, to achieve colon targeting. This article highlights the factors influencing colon-specific drug delivery and colonic bioavailability, and the limitations associated with CDDS. Further, the review provides a systematic discussion of various conventional, as well as relatively newer formulation approaches/technologies currently being utilized for the development of CDDS.
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ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-015-0350-9