Outcome of Chlamydia pneumoniae associated acute ischemic stroke in elderly patients: A case–control study

• Published in: Clinical neurology and neurosurgery Vol. 114; no. 2; pp. 120 - 123
• Main Authors: Srinivasarao Bandaru, V.C.S, Boddu, Demudu Babu, Mridula, K. Rukmini, Akhila, B, Alladi, Suvarna, Laxmi, V, Pathapati, Rammohan, Neeraja, M, Kaul, Subhash
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.02.2012; Elsevier; Elsevier Limited
• Subjects: Aged; Aged, 80 and over; Aging - physiology; Antibodies, Bacterial - analysis; Atherosclerosis; Biological and medical sciences; Brain Ischemia - etiology; Brain Ischemia - therapy; C-Reactive Protein - analysis; Cardiac arrhythmia; Case-Control Studies; Cerebral Small Vessel Diseases - microbiology; Chlamydia; Chlamydia Infections - complications; Chlamydia Infections - microbiology; Chlamydia Infections - therapy; Chlamydia pneumoniae antibodies; Chlamydophila pneumoniae; Diabetes; Disease; Female; Fluorescent Antibody Technique; Follow-Up Studies; Genomics; Humans; Hypertension; Immunoglobulin A - analysis; Immunoglobulin G - analysis; Logistics; Male; Medical imaging; Medical sciences; Microbiology; Microimmunofluorescence; Middle Aged; Modified Rankin score; Multivariate analysis; Neurology; Neurosurgery; Odds Ratio; Outcome of stroke; Prospective Studies; Regression analysis; Risk Factors; Statistical analysis; Stroke; Stroke - etiology; Stroke - therapy; Surfactants; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Treatment Outcome; Outcome of stroke; Chlamydia pneumoniae antibodies; Modified Rankin score; Microimmunofluorescence; Human; Cerebral infarction; Stroke; Chlamydia pneumoniae; Nervous system diseases; Prognosis; Chlamydiaceae; Cardiovascular disease; Case control study; Cerebral disorder; Vascular disease; Surgery; Central nervous system disease; Chlamydiales; Brain ischemia; Bacteria; Elderly; Cerebrovascular disease
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2011.09.016

Abstract Background Limited data exists about the role of Chlamydia pneumoniae elderly patients with acute ischemic stroke. Objective To study the role of C. pneumoniae in elderly patients (age more than 65 years) with acute ischemic stroke and its impact on stroke out come. Methods We recruited 100 elderly patients with acute ischemic stroke and 100 age and sex matched controls over a period of 2 years. IgG and IgA anti C. pneumoniae antibodies were measured by microimmunofluorescence technique in patients and controls. Good outcome was defined as a Modified Rankin score (mRS) of ≤2. Results We found C. pneumoniae antibodies in 35% stroke patients and in 18% control subjects ( p = 0.01). Good out come at 90 days follow up was found in 20/35(57.1%) seropositive stroke patients compared to 37/65(56.9%) seronegative stroke patients ( p = 0.9). Conclusions C. pneumoniae antibody positivity was independently associated with ischemic stroke in elderly patients and its presence does not alter the stroke outcome.