Employing T-Cell Memory to Effectively Target SARS-CoV-2

• Published in: Pathogens (Basel) Vol. 12; no. 2; p. 301
• Main Authors: Tun, Zaw Htet, Htike, Nang Thinn Thinn, Kyi-Tha-Thu, Chaw, Lee, Wing-Hin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2023; MDPI
• Subjects: Abnormalities; Antigens; Containment; Coronaviruses; COVID-19; COVID-19 vaccines; Cytokines; Cytotoxicity; Genotype & phenotype; Health aspects; Hepatitis C; HIV; Human immunodeficiency virus; Immune system; Immunity; Immunologic memory; Immunological memory; Immunological research; Infections; lung TRM; Lymphocytes; Lymphocytes T; Memory cells; Neutrophils; Pandemics; Peptides; Physiological aspects; Respiratory distress syndrome; Review; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; T cells; vaccine; Vaccines; Viral diseases; Viral infections; Malaysia; COVID-19; lung TRM; SARS-CoV-2; vaccine; T cells
• ISSN: 2076-0817; 2076-0817
• DOI: 10.3390/pathogens12020301

Well-trained T-cell immunity is needed for early viral containment, especially with the help of an ideal vaccine. Although most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected convalescent cases have recovered with the generation of virus-specific memory T cells, some cases have encountered T-cell abnormalities. The emergence of several mutant strains has even threatened the effectiveness of the T-cell immunity that was established with the first-generation vaccines. Currently, the development of next-generation vaccines involves trying several approaches to educate T-cell memory to trigger a broad and fast response that targets several viral proteins. As the shaping of T-cell immunity in its fast and efficient form becomes important, this review discusses several interesting vaccine approaches to effectively employ T-cell memory for efficient viral containment. In addition, some essential facts and future possible consequences of using current vaccines are also highlighted.