Elevated interleukin-6 expression levels are associated with intervertebral disc degeneration
The present study aimed to investigate whether serum interleukin-6 (IL-6) expression levels were associated with the onset and progression of intervertebral disc degeneration (IDD). A comprehensive meta-analysis of the scientific literature from numerous electronic databases was performed, in order...
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| Published in | Experimental and therapeutic medicine Vol. 11; no. 4; pp. 1425 - 1432 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Greece
D.A. Spandidos
01.04.2016
Spandidos Publications Spandidos Publications UK Ltd |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1792-0981 1792-1015 |
| DOI | 10.3892/etm.2016.3079 |
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| Abstract | The present study aimed to investigate whether serum interleukin-6 (IL-6) expression levels were associated with the onset and progression of intervertebral disc degeneration (IDD). A comprehensive meta-analysis of the scientific literature from numerous electronic databases was performed, in order to obtain published studies associated with the topic of interest. Relevant case-control studies that had previously assessed a correlation between IL-6 expression levels and IDD were identified using predetermined inclusion and exclusion criteria. The STATA version 12.0 software was used for statistical analysis of the extracted data. A total of 112 studies were initially retrieved, with eight studies meeting the inclusion criteria. These contained a total of 392 subjects, of which 263 were patients with IDD and 129 were healthy controls. A meta-analysis of the eight studies demonstrated that serum IL-6 protein expression levels may be associated with IDD, and this was irrespective of IDD subtype (bulging, protrusion, or sequestration). Notably, serum expression levels of the IL-6 protein were upregulated in intervertebral disc (IVD) protrusion tissue, as compared with normal IVD tissue; thus suggesting that IL-6 may have an important role in the pathophysiological process of IDD. |
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| AbstractList | The present study aimed to investigate whether serum interleukin-6 (IL-6) expression levels were associated with the onset and progression of intervertebral disc degeneration (IDD). A comprehensive meta-analysis of the scientific literature from numerous electronic databases was performed, in order to obtain published studies associated with the topic of interest. Relevant case-control studies that had previously assessed a correlation between IL-6 expression levels and IDD were identified using predetermined inclusion and exclusion criteria. The STATA version 12.0 software was used for statistical analysis of the extracted data. A total of 112 studies were initially retrieved, with eight studies meeting the inclusion criteria. These contained a total of 392 subjects, of which 263 were patients with IDD and 129 were healthy controls. A meta-analysis of the eight studies demonstrated that serum IL-6 protein expression levels may be associated with IDD, and this was irrespective of IDD subtype (bulging, protrusion, or sequestration). Notably, serum expression levels of the IL-6 protein were upregulated in intervertebral disc (IVD) protrusion tissue, as compared with normal IVD tissue; thus suggesting that IL-6 may have an important role in the pathophysiological process of IDD. The present study aimed to investigate whether serum interleukin-6 (IL-6) expression levels were associated with the onset and progression of intervertebral disc degeneration (IDD). A comprehensive meta-analysis of the scientific literature from numerous electronic databases was performed, in order to obtain published studies associated with the topic of interest. Relevant case-control studies that had previously assessed a correlation between IL-6 expression levels and IDD were identified using predetermined inclusion and exclusion criteria. The STATA version 12.0 software was used for statistical analysis of the extracted data. A total of 112 studies were initially retrieved, with eight studies meeting the inclusion criteria. These contained a total of 392 subjects, of which 263 were patients with IDD and 129 were healthy controls. A meta-analysis of the eight studies demonstrated that serum IL-6 protein expression levels may be associated with IDD, and this was irrespective of IDD subtype (bulging, protrusion, or sequestration). Notably, serum expression levels of the IL-6 protein were upregulated in intervertebral disc (IVD) protrusion tissue, as compared with normal IVD tissue; thus suggesting that IL-6 may have an important role in the pathophysiological process of IDD. Key words: interleukin-6, intervertebral disc, intervertebral disc degeneration, meta-analysis The present study aimed to investigate whether serum interleukin-6 (IL-6) expression levels were associated with the onset and progression of intervertebral disc degeneration (IDD). A comprehensive meta-analysis of the scientific literature from numerous electronic databases was performed, in order to obtain published studies associated with the topic of interest. Relevant case-control studies that had previously assessed a correlation between IL-6 expression levels and IDD were identified using predetermined inclusion and exclusion criteria. The STATA version 12.0 software was used for statistical analysis of the extracted data. A total of 112 studies were initially retrieved, with eight studies meeting the inclusion criteria. These contained a total of 392 subjects, of which 263 were patients with IDD and 129 were healthy controls. A meta-analysis of the eight studies demonstrated that serum IL-6 protein expression levels may be associated with IDD, and this was irrespective of IDD subtype (bulging, protrusion, or sequestration). Notably, serum expression levels of the IL-6 protein were upregulated in intervertebral disc (IVD) protrusion tissue, as compared with normal IVD tissue; thus suggesting that IL-6 may have an important role in the pathophysiological process of IDD.The present study aimed to investigate whether serum interleukin-6 (IL-6) expression levels were associated with the onset and progression of intervertebral disc degeneration (IDD). A comprehensive meta-analysis of the scientific literature from numerous electronic databases was performed, in order to obtain published studies associated with the topic of interest. Relevant case-control studies that had previously assessed a correlation between IL-6 expression levels and IDD were identified using predetermined inclusion and exclusion criteria. The STATA version 12.0 software was used for statistical analysis of the extracted data. A total of 112 studies were initially retrieved, with eight studies meeting the inclusion criteria. These contained a total of 392 subjects, of which 263 were patients with IDD and 129 were healthy controls. A meta-analysis of the eight studies demonstrated that serum IL-6 protein expression levels may be associated with IDD, and this was irrespective of IDD subtype (bulging, protrusion, or sequestration). Notably, serum expression levels of the IL-6 protein were upregulated in intervertebral disc (IVD) protrusion tissue, as compared with normal IVD tissue; thus suggesting that IL-6 may have an important role in the pathophysiological process of IDD. |
| Audience | Academic |
| Author | KANG, BAOLIN ZHAO, FENG ZHANG, XIN DENG, XIAO |
| AuthorAffiliation | Department of Orthopedics, Shaanxi Sengong Hospital, Xi'an, Shaanxi 710300, P.R. China |
| AuthorAffiliation_xml | – name: Department of Orthopedics, Shaanxi Sengong Hospital, Xi'an, Shaanxi 710300, P.R. China |
| Author_xml | – sequence: 1 givenname: XIAO surname: DENG fullname: DENG, XIAO organization: Department of Orthopedics, Shaanxi Sengong Hospital, Xi'an, Shaanxi 710300, P.R. China – sequence: 2 givenname: FENG surname: ZHAO fullname: ZHAO, FENG organization: Department of Orthopedics, Shaanxi Sengong Hospital, Xi'an, Shaanxi 710300, P.R. China – sequence: 3 givenname: BAOLIN surname: KANG fullname: KANG, BAOLIN organization: Department of Orthopedics, Shaanxi Sengong Hospital, Xi'an, Shaanxi 710300, P.R. China – sequence: 4 givenname: XIN surname: ZHANG fullname: ZHANG, XIN organization: Department of Orthopedics, Shaanxi Sengong Hospital, Xi'an, Shaanxi 710300, P.R. China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27073460$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2016, Spandidos Publications COPYRIGHT 2016 Spandidos Publications Copyright Spandidos Publications UK Ltd. 2016 Copyright © 2016, Spandidos Publications 2016 |
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| Snippet | The present study aimed to investigate whether serum interleukin-6 (IL-6) expression levels were associated with the onset and progression of intervertebral... |
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| SubjectTerms | Age Confidence intervals Cytokines Development and progression Disease Ethnicity Gender Gene expression Genetic aspects Growth factors Hernia Interleukin-6 intervertebral disc intervertebral disc degeneration Intervertebral disk Intervertebral disk displacement Meta-analysis Pain Physiological aspects Protein expression Proteins Risk factors Studies |
| Title | Elevated interleukin-6 expression levels are associated with intervertebral disc degeneration |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/27073460 https://www.proquest.com/docview/1931023140 https://www.proquest.com/docview/1859709609 https://pubmed.ncbi.nlm.nih.gov/PMC4812581 |
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