Elevated interleukin-6 expression levels are associated with intervertebral disc degeneration

• Published in: Experimental and therapeutic medicine Vol. 11; no. 4; pp. 1425 - 1432
• Main Authors: DENG, XIAO, ZHAO, FENG, KANG, BAOLIN, ZHANG, XIN
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.04.2016; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Age; Confidence intervals; Cytokines; Development and progression; Disease; Ethnicity; Gender; Gene expression; Genetic aspects; Growth factors; Hernia; Interleukin-6; intervertebral disc; intervertebral disc degeneration; Intervertebral disk; Intervertebral disk displacement; Meta-analysis; Pain; Physiological aspects; Protein expression; Proteins; Risk factors; Studies; China; intervertebral disc degeneration; meta-analysis; intervertebral disc; interleukin-6
• ISSN: 1792-0981; 1792-1015
• DOI: 10.3892/etm.2016.3079

The present study aimed to investigate whether serum interleukin-6 (IL-6) expression levels were associated with the onset and progression of intervertebral disc degeneration (IDD). A comprehensive meta-analysis of the scientific literature from numerous electronic databases was performed, in order to obtain published studies associated with the topic of interest. Relevant case-control studies that had previously assessed a correlation between IL-6 expression levels and IDD were identified using predetermined inclusion and exclusion criteria. The STATA version 12.0 software was used for statistical analysis of the extracted data. A total of 112 studies were initially retrieved, with eight studies meeting the inclusion criteria. These contained a total of 392 subjects, of which 263 were patients with IDD and 129 were healthy controls. A meta-analysis of the eight studies demonstrated that serum IL-6 protein expression levels may be associated with IDD, and this was irrespective of IDD subtype (bulging, protrusion, or sequestration). Notably, serum expression levels of the IL-6 protein were upregulated in intervertebral disc (IVD) protrusion tissue, as compared with normal IVD tissue; thus suggesting that IL-6 may have an important role in the pathophysiological process of IDD.