HPV-Related Papillary Lesions of the Oral Mucosa: A Review

• Published in: Head & neck pathology (Totowa, N.J.) Vol. 13; no. 1; pp. 80 - 90
• Main Author: Betz, Sasha J.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2019
• Subjects: a Review of Oral Mucosal Entities; Dentistry; Humans; Medicine; Medicine & Public Health; Mouth Diseases - pathology; Mouth Diseases - virology; Mouth Mucosa - pathology; Mouth Mucosa - virology; Oral and Maxillofacial Surgery; Otorhinolaryngology; Papillomavirus Infections - pathology; Pathology; Special Issue: Colors and Textures; Special Issue: Colors and Textures, a Review of Oral Mucosal Entities; Oral warts; Human papillomavirus; Squamous cell carcinoma; HPV transmission; Squamous papilloma; Multifocal epithelial hyperplasia
• ISSN: 1936-0568; 1936-055X; 1936-0568
• DOI: 10.1007/s12105-019-01003-7

Human papillomaviruses (HPVs) are causative of a group of clinically papillary lesions. The HPV-related lesions of the oral cavity include squamous papilloma, condyloma acuminatum, verruca vulgaris, and multifocal epithelial hyperplasia. Benign entities, such as verruciform xanthoma or giant cell fibroma, as well as malignancies, such as papillary squamous cell carcinoma and verrucous carcinoma, may be considered in the clinical and/or histologic differential diagnoses of these lesions. Mechanisms of infection, epidemiology, clinical presentations, histologic features, and differential diagnoses of the HPV-related oral pathologies are discussed. Current concepts of viral transmission, especially as pertaining to lesions in pediatric patients, and the impacts of HPV vaccination are reviewed.