Neuropeptide Y signaling in the dorsal raphe nucleus inhibits male sexual behavior in mice

• Published in: Neuroscience Vol. 320; pp. 140 - 148
• Main Authors: Inaba, A, Komori, Y, Muroi, Y, Kinoshita, K, Ishii, T
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 21.04.2016
• Subjects: Animals; dorsal raphe nucleus; Dorsal Raphe Nucleus - metabolism; Fasting; Immunohistochemistry; Male; male sexual behavior; Mice; Neurology; neuropeptide Y; Neuropeptide Y - metabolism; Serotonergic Neurons - metabolism; serotonin; Sexual Behavior, Animal - physiology; Signal Transduction - physiology; median raphe nucleus; PBS; DRN; VTA; Triton X-100 in PBS; neuropeptide Y; MRN; medial preoptic area; TPBS; male sexual behavior; phosphate-buffered saline; TPH; 8-OH-DPAT; (±)-8-hydroxy-2-dipropylaminotetralin; serotonin or 5-hyrodxytryptamine; dorsal raphe nucleus; MPOA; serotonin; ventral tegmental area; (+)-DOI hydrochloride; NPY; tryptophan hydroxylase; 5-HT; DOI
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2016.01.069

Highlights • Male sexual behavior is inhibited under a low energy condition. • NPY-positive neuronal processes are distributed in the dorsal raphe nucleus. • The Y1 receptor is expressed in serotonergic neurons of the dorsal raphe nucleus. • NPY inhibits male sexual behavior via the Y1 receptor in the dorsal raphe nucleus.