Developmental changes in KCC1, KCC2, and NKCC1 mRNA expressions in the rat brain

• Published in: Brain research. Developmental brain research Vol. 139; no. 1; pp. 59 - 66
• Main Authors: Wang, Cong, Shimizu-Okabe, Chigusa, Watanabe, Kazuo, Okabe, Akihito, Matsuzaki, Hideo, Ogawa, Tsuguhiro, Mori, Norio, Fukuda, Atsuo, Sato, Kohji
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.11.2002
• Subjects: Animals; Brain - embryology; Brain - growth & development; Brain Chemistry - physiology; Cation–chloride cotransporter; Chloride homeostasis; Chlorides - metabolism; Epithelial Cells - metabolism; Female; Hippocampus - metabolism; In situ hybridization; K Cl- Cotransporters; Male; Pregnancy; Rats; RNA Probes; RNA, Messenger - biosynthesis; Sodium-Potassium-Chloride Symporters - biosynthesis; Solute Carrier Family 12, Member 2; Symporters - biosynthesis; Chloride homeostasis; Cation–chloride cotransporter; In situ hybridization; Neurotransmitters, modulators, transporters, and receptors

We investigated the expressions of KCC1, KCC2 and NKCC1 mRNAs in the developing rat brain. The neuroepithelium showed abundant KCC1 and NKCC1 mRNA expressions, while KCC2 mRNA was not detected there. In contrast, KCC2 mRNA was preferentially expressed in postmitotic mature neurons. These results sug...