Developmental changes in KCC1, KCC2, and NKCC1 mRNA expressions in the rat brain

We investigated the expressions of KCC1, KCC2 and NKCC1 mRNAs in the developing rat brain. The neuroepithelium showed abundant KCC1 and NKCC1 mRNA expressions, while KCC2 mRNA was not detected there. In contrast, KCC2 mRNA was preferentially expressed in postmitotic mature neurons. These results sug...

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Published inBrain research. Developmental brain research Vol. 139; no. 1; pp. 59 - 66
Main Authors Wang, Cong, Shimizu-Okabe, Chigusa, Watanabe, Kazuo, Okabe, Akihito, Matsuzaki, Hideo, Ogawa, Tsuguhiro, Mori, Norio, Fukuda, Atsuo, Sato, Kohji
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.11.2002
Subjects
Animals
Brain - embryology
Brain - growth & development
Brain Chemistry - physiology
Cation–chloride cotransporter
Chloride homeostasis
Chlorides - metabolism
Epithelial Cells - metabolism
Female
Hippocampus - metabolism
In situ hybridization
K Cl- Cotransporters
Male
Pregnancy
Rats
RNA Probes
RNA, Messenger - biosynthesis
Sodium-Potassium-Chloride Symporters - biosynthesis
Solute Carrier Family 12, Member 2
Symporters - biosynthesis
Chloride homeostasis
Cation–chloride cotransporter
In situ hybridization
Neurotransmitters, modulators, transporters, and receptors
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Summary:We investigated the expressions of KCC1, KCC2 and NKCC1 mRNAs in the developing rat brain. The neuroepithelium showed abundant KCC1 and NKCC1 mRNA expressions, while KCC2 mRNA was not detected there. In contrast, KCC2 mRNA was preferentially expressed in postmitotic mature neurons. These results suggest that the appearance of KCC2 expression mainly depends on the maturation of individual neurons.
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ISSN:0165-3806
DOI:10.1016/S0165-3806(02)00536-9