Developmental changes in KCC1, KCC2, and NKCC1 mRNA expressions in the rat brain

We investigated the expressions of KCC1, KCC2 and NKCC1 mRNAs in the developing rat brain. The neuroepithelium showed abundant KCC1 and NKCC1 mRNA expressions, while KCC2 mRNA was not detected there. In contrast, KCC2 mRNA was preferentially expressed in postmitotic mature neurons. These results sug...

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Published in	Brain research. Developmental brain research Vol. 139; no. 1; pp. 59 - 66
Main Authors	Wang, Cong, Shimizu-Okabe, Chigusa, Watanabe, Kazuo, Okabe, Akihito, Matsuzaki, Hideo, Ogawa, Tsuguhiro, Mori, Norio, Fukuda, Atsuo, Sato, Kohji
Format	Journal Article
Language	English
Published	Netherlands Elsevier B.V 15.11.2002
Subjects	Animals Brain - embryology Brain - growth & development Brain Chemistry - physiology Cation–chloride cotransporter Chloride homeostasis Chlorides - metabolism Epithelial Cells - metabolism Female Hippocampus - metabolism In situ hybridization K Cl- Cotransporters Male Pregnancy Rats RNA Probes RNA, Messenger - biosynthesis Sodium-Potassium-Chloride Symporters - biosynthesis Solute Carrier Family 12, Member 2 Symporters - biosynthesis Chloride homeostasis Cation–chloride cotransporter In situ hybridization Neurotransmitters, modulators, transporters, and receptors
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Abstract	We investigated the expressions of KCC1, KCC2 and NKCC1 mRNAs in the developing rat brain. The neuroepithelium showed abundant KCC1 and NKCC1 mRNA expressions, while KCC2 mRNA was not detected there. In contrast, KCC2 mRNA was preferentially expressed in postmitotic mature neurons. These results suggest that the appearance of KCC2 expression mainly depends on the maturation of individual neurons.
AbstractList	We investigated the expressions of KCC1, KCC2 and NKCC1 mRNAs in the developing rat brain. The neuroepithelium showed abundant KCC1 and NKCC1 mRNA expressions, while KCC2 mRNA was not detected there. In contrast, KCC2 mRNA was preferentially expressed in postmitotic mature neurons. These results suggest that the appearance of KCC2 expression mainly depends on the maturation of individual neurons. We investigated the expressions of KCC1, KCC2 and NKCC1 mRNAs in the developing rat brain. The neuroepithelium showed abundant KCC1 and NKCC1 mRNA expressions, while KCC2 mRNA was not detected there. In contrast, KCC2 mRNA was preferentially expressed in postmitotic mature neurons. These results suggest that the appearance of KCC2 expression mainly depends on the maturation of individual neurons.We investigated the expressions of KCC1, KCC2 and NKCC1 mRNAs in the developing rat brain. The neuroepithelium showed abundant KCC1 and NKCC1 mRNA expressions, while KCC2 mRNA was not detected there. In contrast, KCC2 mRNA was preferentially expressed in postmitotic mature neurons. These results suggest that the appearance of KCC2 expression mainly depends on the maturation of individual neurons.
Author	Shimizu-Okabe, Chigusa Fukuda, Atsuo Wang, Cong Sato, Kohji Okabe, Akihito Matsuzaki, Hideo Ogawa, Tsuguhiro Mori, Norio Watanabe, Kazuo
Author_xml	– sequence: 1 givenname: Cong surname: Wang fullname: Wang, Cong organization: Department of Anatomy and Neuroscience, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan – sequence: 2 givenname: Chigusa surname: Shimizu-Okabe fullname: Shimizu-Okabe, Chigusa organization: Department of Physiology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan – sequence: 3 givenname: Kazuo surname: Watanabe fullname: Watanabe, Kazuo organization: Department of Anatomy and Neuroscience, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan – sequence: 4 givenname: Akihito surname: Okabe fullname: Okabe, Akihito organization: Department of Physiology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan – sequence: 5 givenname: Hideo surname: Matsuzaki fullname: Matsuzaki, Hideo organization: Department of Anatomy and Neuroscience, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan – sequence: 6 givenname: Tsuguhiro surname: Ogawa fullname: Ogawa, Tsuguhiro organization: Department of Anatomy and Neuroscience, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan – sequence: 7 givenname: Norio surname: Mori fullname: Mori, Norio organization: Department of Psychiatry, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan – sequence: 8 givenname: Atsuo surname: Fukuda fullname: Fukuda, Atsuo organization: Department of Physiology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan – sequence: 9 givenname: Kohji surname: Sato fullname: Sato, Kohji email: ksato@hama-med.ac.jp organization: Department of Anatomy and Neuroscience, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan
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Keywords	Chloride homeostasis Cation–chloride cotransporter In situ hybridization Neurotransmitters, modulators, transporters, and receptors
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Snippet	We investigated the expressions of KCC1, KCC2 and NKCC1 mRNAs in the developing rat brain. The neuroepithelium showed abundant KCC1 and NKCC1 mRNA expressions,...
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SubjectTerms	Animals Brain - embryology Brain - growth & development Brain Chemistry - physiology Cation–chloride cotransporter Chloride homeostasis Chlorides - metabolism Epithelial Cells - metabolism Female Hippocampus - metabolism In situ hybridization K Cl- Cotransporters Male Pregnancy Rats RNA Probes RNA, Messenger - biosynthesis Sodium-Potassium-Chloride Symporters - biosynthesis Solute Carrier Family 12, Member 2 Symporters - biosynthesis
Title	Developmental changes in KCC1, KCC2, and NKCC1 mRNA expressions in the rat brain
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