Injectable matrices and scaffolds for drug delivery in tissue engineering

• Published in: Advanced drug delivery reviews Vol. 59; no. 4; pp. 263 - 273
• Main Authors: Kretlow, James D., Klouda, Leda, Mikos, Antonios G.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 30.05.2007; Elsevier Science
• Subjects: Biocompatible Materials - chemistry; Biological and medical sciences; Biomaterials; Drug delivery; Drug Delivery Systems; General pharmacology; Humans; Injectable; Injections; Intercellular Signaling Peptides and Proteins - administration & dosage; Materials Testing; Medical sciences; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Scaffolds; Tissue engineering; Tissue Engineering - methods; PBS; Injectable; APS; OPF; PLA; DMSO; Tissue engineering; PPF; Drug delivery; GAG; Biomaterials; NMP; PAA; PEG; PLGA; PVA; LCST; TEMED; Scaffolds; PNIPAAm; Tissue; Injectable form; Pharmaceutical technology; Regenerative medicine; Drug carrier; Biomaterial; Scaffold
• ISSN: 0169-409X; 1872-8294
• DOI: 10.1016/j.addr.2007.03.013

Injectable matrices and depots have been the subject of much research in the field of drug delivery. The classical tissue engineering paradigm includes a matrix or scaffold to facilitate tissue growth and provide structural support, cells, and the delivery of bioactive molecules. As both tissue engineering and drug delivery techniques benefit from the use of injectable materials due to the minimal invasiveness of an injection, significant crossover should be observed between injectable materials in both fields. This review aims to outline injectable materials and processing techniques used in both tissue engineering and drug delivery and to describe methods by which current injectable materials in the field of drug delivery can be adapted for use as injectable scaffolds for tissue engineering.