Cell Therapy as a Tool for Induction of Immunological Tolerance after Liver Transplantation

Transplantation of solid organs, including liver, induces a number of serious complications related to immune incompatibility and requiring long-term use of immunosuppressive drugs. Finding the ways to inducing recipient immunological tolerance to the grafts is a top priority in organ transplantatio...

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Published inBulletin of experimental biology and medicine Vol. 165; no. 4; pp. 554 - 563
Main Authors Kholodenko, I. V., Kholodenko, R. V., Lupatov, A. Yu, Yarygin, K. N.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2018
Springer
Subjects
Allografts
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell- and Tissue-Based Therapy - methods
Humans
Immunosuppression
Immunotherapy
Internal Medicine
Laboratory Medicine
Liver Transplantation
Pathology
T cells
T-Lymphocytes, Regulatory - immunology
regulatory T cells
operational tolerance
immunosuppression
cell therapy
liver transplantation
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Summary:Transplantation of solid organs, including liver, induces a number of serious complications related to immune incompatibility and requiring long-term use of immunosuppressive drugs. Finding the ways to inducing recipient immunological tolerance to the grafts is a top priority in organ transplantation and immunology. Along with the search for immunosupressive therapy, the development of alternative approaches to induction of immunological tolerance based on cell technologies is now in progress. In this regard, studies of the so-called spontaneous operational tolerance observed in ~20% patients after orthotopic liver transplantation is a promising trend. Understanding of this phenomenon can shed light on the mechanisms of immunological tolerance to allografts and will help to identify specific tolerance biomarkers and cell types with the aptitude for the induction of tolerance to liver allografts.
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-018-4213-8