Differences in quantitative EEG between frontotemporal dementia and Alzheimer’s disease as revealed by LORETA

• Published in: Clinical neurophysiology Vol. 122; no. 9; pp. 1718 - 1725
• Main Authors: Nishida, K, Yoshimura, M, Isotani, T, Yoshida, T, Kitaura, Y, Saito, A, Mii, H, Kato, M, Takekita, Y, Suwa, A, Morita, S, Kinoshita, T
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ireland Ltd 01.09.2011; Elsevier
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - diagnosis; Alzheimer Disease - physiopathology; Alzheimer’s disease; Beta rhythm; Biological and medical sciences; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; EEG; Electrodiagnosis. Electric activity recording; Electroencephalography; Female; Frontotemporal dementia; Frontotemporal Dementia - diagnosis; Frontotemporal Dementia - physiopathology; Humans; Investigative techniques, diagnostic techniques (general aspects); LORETA; Male; Medical sciences; Middle Aged; Nervous system; Neurology; Quantitative EEG; Sensorimotor area; Signal Processing, Computer-Assisted; Beta rhythm; Alzheimer’s disease; EEG; Quantitative EEG; Frontotemporal dementia; LORETA; Sensorimotor area; Frontal lobe; Alzheimer disease; Central nervous system; Electrophysiology; Electroencephalography; Encephalon; Frequency band; Tomography; Degenerative disease; Localization; Alzheimer's disease; Human; Temporal lobe; Nervous system diseases; Cerebral disorder; Electric field; Analysis method; Central nervous system disease; Parietal lobe; Strength
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2011.02.011

Research highlights ► A comparative study of frontotemporal dementia (FTD), Alzheimer’s disease (AD), and healthy control subjects (NC) was carried out in terms of the cortical localization of oscillatory EEG activity. ► As compared to NC, FTD had significantly reduced alpha generators in fronto-temporal cortices, while AD showed significantly stronger delta generators that included the frontal lobes. ► ROC curves demonstrate a moderate separation of FTD, AD, and NC groups.